The interaction between nevi, which are congenital or acquired benign melanocytic proliferations, and melanoma is still enigmatic. Authors of this review discuss clinical, histological, molecular, and genetic factors that influence nevus formation and progression to melanoma.
According to this recent study, wearing a device that measured and alerted melanoma survivors to UVR exposure did not result in different sun behaviors, exposure, or sunburns relative to controls. The technology needs refinement before further attempts to assess the effectiveness of self-monitoring UVR exposure.
According to this recent study, the injectable temperature-sensitive PPMSs/DDP@Gel is a promising candidate for the local treatment of melanoma. Anti-tumor studies have shown that the PPMSs/DDP@Gel significantly inhibited tumor growth, prolonged the survival of tumor-bearing mice, and had no obvious toxic side effects on major organs.
According to this recent study, the immunosuppressive drug methotrexate can be linked to an elevated risk of basal cell carcinoma, squamous cell carcinoma and cutaneous malignant melanoma. Patients receiving the drug include those with moderate to severe psoriasis; but in this particular patient group, a risk increase was only observed for basal cell carcinoma.
Three-dimensional (3D) total-body photography is a recent advance in melanoma early detection that can aid in monitoring and identifying new and changing skin lesions over time. Participant feedback indicated a high level of acceptance and confidence in the technology. To facilitate clinical translation, addressing consumer-identified barriers to 3D total-body photography will be vital.
The objective of this narrative review is to describe current and ongoing research in the use of topical photosensitizers and modified light delivery regimens to achieve improved therapeutic outcomes with less toxicity in patients with actinic keratoses, cutaneous squamous cell carcinomas, basal cell carcinomas, and field cancerization.
Authors of this recent study propose that the inner nuclear membrane proteinLAP1 renders the nucleus highly adaptable and contributes to melanoma aggressiveness.
Authors of this study state that the implementation of the newly revised MPATH-Dx version 2.0 schema into clinical practice is anticipated to provide a robust tool and adjunct for standardized diagnostic reporting of melanocytic lesions and management of patients to the benefit of both health care practitioners and patients.
According to this recent study, the patient population undergoing isolated limb perfusion (ILP) for in-transit melanoma is largely unchanged in the current era of effective systemic treatments. Response rates have not decreased, and prior immune checkpoint inhibitors (ICI) treatment did not affect response rates, making ILP still a valid treatment option for this patient group.
This review discusses recent findings in melanoma phenotype switching, immunotherapy resistance, and the balancing of the homeostatic tumor microenvironment between the different melanoma cell subpopulations. Authors also discuss future perspectives of the biology of neural crest-like state(s) in melanoma.