Findings of this recent study suggest that long-term continuous irradiation with blue light induces neutrophil NETosis and an increase in type 1 macrophages, resulting in skin cancer.
According to this recent study, SIRT6 plays a role in skin carcinogenesis, and results of the study suggest SIRT6 pharmacological inhibition as a promising strategy in cutaneous Squamous Cell Carcinoma (cSCC).
Authors of this article review the role of immune checkpoints in melanoma; the history of melanoma immunotherapy; pivotal clinical trial data for ipilimumab, pembrolizumab, nivolumab and relatlimab; and the current clinical role of each immune checkpoint inhibitors (ICI). They also discuss challenges.
According to this recent molecular analysis of patients with resected melanoma brain metastases, BRAF V600E alteration is an important translational biomarker associated with worse clinical outcomes, differential microenvironmental composition, and benefit from immunotherapy. Patients with BRAF V600E variant melanoma brain metastases may thus benefit from alternative CNS-penetrant systemic regimens.
The American Society of Clinical Oncology conducted an updated systematic review of the literature to provide guidance to clinicians regarding the use of systemic therapy for melanoma.
This recent research aims to construct a model based on necroptosis-related long non-coding RNAs for the prognosis of patients with melanoma. The study concludes that this prognostic model can independently predict the survival of melanoma patients while providing a basis for the subsequent investigation of necroptosis in melanoma and a new perspective on the clinical diagnosis and treatment of melanoma.
Previous research studies are typically siloed into the separate areas of vitamin D or skin cancer research. This recent study incorporated both topics and pooled the views of participants in two citizens' juries who agreed on the need for improved information about the harms and benefits of sun exposure to reflect a modern Australian population.
According to this recent study, post-treatment cancer survivorship should be established as a distinct phase of cancer care. Measures could include greater leadership in the survivorship space, the implementation of a survivorship model(s) of care and the use of survivorship care plans.
This study aimed to investigate the supportive care needs of Australian melanoma patients and their caregivers to form the basis for improving services. It found that Australian melanoma patients and caregivers frequently report unmet supportive care needs, particularly regarding their psychological and emotional well-being, and suggests psychological and emotional well-being services, such as access to a clinical psychologist or implementation of patient-reported outcome measures, should be incorporated into routine melanoma care.
This recent study demonstrates how in silico drug target prediction based on metabolic modelling can be a useful complement in the selection of tailored treatments to improve the therapeutic outcome of melanoma patients especially for those that relapse or do not respond to current melanoma treatments.