Integrated photoacoustic and hyperspectral dual modality microscope for co-imaging of melanoma and cutaneous squamous cell carcinoma
May 21, 2020
Abstract
Skin carcinoma such as melanoma (MM) and cutaneous squamous cell carcinoma (cSCC) are considered as the highest mortality and the most aggressive skin cancers in dermatology. In view that early diagnosis and treatment can greatly improve the survival rate and life quality of the patients, developing noninvasive and effective evaluation methods is of great significance for the detection and identification of early stage cutaneous cancers. In this letter, we proposed a hybrid photoacoustic and hyperspectral dual modality microscope (PAHSM) to evaluate and differentiate skin carcinoma by structural and multi physiological parameters. The proposed system's imaging abilities were verified by mimic phantoms and normal mice experiments. Furthermore, in vivo characterization and evaluation results of MM and cSCC mice were obtained successfully, which proved this novel method could be used as a reliable and useful method for skin cancer detection in early stages.
Source:
Liu N, Chen Z, Xing D. Integrated photoacoustic and hyperspectral dual modality microscope for co-imaging of melanoma and cutaneous squamous cell carcinoma in vivo. Journal of Biophotonics. 2020 May:e202000105. DOI: 10.1002/jbio.202000105.