Risk factors for lower extremity lymphedema after Inguinal lymphadenectomy in melanoma patients
February 20, 2022
Abstract
Background:
The aim of lymph node (LN) dissection for melanoma patients is to prevent metastasis. However, this procedure is accompanied by a long-term and impaired life-quality complication called extremity lymphedema. This condition involves long-term lower limb swelling, which causes discomfort and impaired function, and affects patients both physically and psychologically. Herein, we conducted a retrospective cohort study at a single center to investigate the risk factors associated with lower extremity lymphedema (LEL) after inguinal lymphadenectomy.
Materials and Methods:
We identified 136 inguinal lymphadenectomy melanoma patients treated between January 2010 and January 2021. The patients' demographic, clinical, pathological data, and postoperative outcomes were collected by electronic medical record review and patient follow-up. The patients' postoperative outcomes were defined as lower extremity swelling (LES) and LEL. Univariate and multivariate analyses were used to determine the independent predictors of LEL.
Results:
The follow-up results from 85 melanoma patients who underwent inguinal lymphadenectomy were analyzed. Multivariate logistic regression analysis showed that the number of LNs removed ≥ 10 was the significant risk factor for postoperative LEL [odds ratio (OR)=6.468, P = 0.042, 95% confidence interval (CI): 1.069 to 39.147]. Moreover, eight (100%) patients in the LEL group and 32 (53.3%) patients in the normal group were females, which indicated that female patients might be more susceptible to postoperative LEL (P = 0.012).
Conclusions:
Our study found that the number of inguinal LNs removed ≥ 10 was associated with a significantly higher incidence of LEL with a 6.5-fold increased risk in melanoma patients. Also, female patients were more likely to develop LEL after inguinal lymphadenectomy.
Source:
Tianzhe Chen, M.M Yue Lin, Qian Tan, Risk Factors for Lower Extremity Lymphedema after Inguinal Lymphadenectomy in Melanoma Patients: A Retrospective Cohort Study, Surgery Open Science, 2022, ,ISSN 2589-8450, https://doi.org/10.1016/j.sopen.2022.02.001.