22 May 2023According to this recent study there is a clear association between earlier stage at skin cancer detection and decreased mortality risk. Results suggest no melanoma mortality benefit associated with skin cancer screening in adolescents or adults in regions with implemented routine screening compared to regions without routine screening. Results suggest no association between routine clinician skin examination and earlier stage at melanoma detection. There appears to be little direct evidence on harms of screening.
8 May 2023According to this recent study, melanoma brain metastasis patients treated with either ipilimumab–nivolumab or nivolumab did not report a significant deterioration in health-related quality of life within 18 weeks of treatment initiation, providing support for the use of these immunotherapies as first-line treatment for melanoma brain metastases.
8 May 2023This recent study explores the impact of liquid–liquid phase separation (LLPS)-related genes on melanoma prognosis. It concludes that the gene signature can independently predict the survival of melanoma patients and provides a basis for the exploration of the relationship between LLPS and melanoma.
8 May 2023According to this recent research, supportive care interventions have positive impacts on melanoma patient well-being outcomes, while being acceptable and feasible to conduct. Authors state that more research was needed regarding supportive care interventions for melanoma caregivers.
7 May 2023This review provides an overview of the screening, diagnosis and management of melanoma in Australia.
7 May 2023Review on genetics related to melanoma tumorigenesis, metastasis, and prognosis, and on genetics affecting the melanoma tumor microenvironment and its relation to tumor progression and treatment.
7 May 2023Authors of the recent TRoPICS study observed a positive association between higher predicted risk of skin cancer and the prescription of chemoprophylaxis and health-care costs involved with opportunistic community skin cancer screening. A clinical use of risk stratification may be to provide an opportunity for clinicians to discuss skin cancer prevention and chemoprophylaxis with individual patients.
7 May 2023According to this recent study, maintaining the vitamin D level within the normal range during anti-PD-1 immunotherapy in advanced melanoma patients should be a standard procedure allowing the improvement of treatment outcomes.
5 May 2023According to this recent study, systematically producing and exploiting more accurate sentinel lymph node biopsy (SLNB)-positivity probabilities could improve the selection of patients with melanoma for SLNB compared with using established guidelines, thus improving the cost-effectiveness of the selection process. Eligibility guidelines to undergo SLNB should include a context-tailored minimum cutoff probability.
5 May 2023The Great Debate session at the 2022 Melanoma Bridge congress (December 1–3) featured counterpoint views from leading experts on the following contemporary topics of debate in the management of melanoma: the choice of anti-lymphocyte-activation gene (LAG)-3 therapy or ipilimumab in combination with anti-programmed death (PD)-1 therapy, whether anti-PD-1 monotherapy is still acceptable as a comparator arm in clinical trials, whether adjuvant treatment of melanoma is still a useful treatment option, the role of adjuvant therapy in stage II melanoma, what role surgery will continue to have in the treatment of melanoma.
