According to this recent study, survival rates for children and adolescents with melanomas were high. Ulceration, head or neck location and Breslow thickness >4 mm predicted worse survival in adolescents.
Is sentinel node biopsy (SNB) no longer required for patients with T3 and T4 primary melanomas? Authors of this recent paper propse that in the absence of prospective data, the optimal management of the regional node-field for high-risk T3b and T4 primary melanomas is likely to be achieved by combining SNB and adjuvant immunotherapy for those patients who are suitable, rather than either treatment alone.
Authors of this recent study comprehensively profile immune checkpoint inhibitor resistance mechanisms in short-term tumor cell lines and matched tumor samples from melanoma patients progressing on immune checkpoint inhibitors.
Authors of this recent study proposed a free AI-powered self-examination tool allowing everyone to perform regular skin checkups with a smartphone's photo coupled with the new set of risk factors suitable for self-assessment. The study concludes that the proposed approach proved to be a cost-efficient way of doing mass skin cancer screenings.
According to this recent study, baseline IFN-γ (interferon-γ) score adequately differentiated patients who were likely to benefit from nivolumab alone versus patients who require other therapies.
This study aims to compare the surgical outcomes of patients with high-risk stage III melanoma who received neoadjuvant systemic therapy followed by lymph node dissection with patients who received an upfront lymph node dissection. The study concludes that surgical outcomes are comparable.
According to this recent study, rare immune related adverse events associated with ICIs in melanoma patients occurred, in aggregate, in 2–5% of patients treated with anti-PD-1-based therapy. Steroid re-escalation and alternative immunosuppression use were frequently required but fatal Immune-related adverse events were fairly uncommon.
The aim of this recent study was to investigate whether a past or present atopic disorder is associated with cutaneous photodamage, pigment cell nevi and skin cancers. It concludes that the atopy, especially mucus membrane atopy, is associated with lower percentages of subjects with a history of melanoma.
Using an adaptation of the World Health Organization framework for clinical adherence, this scoping review of randomized clinical trials identified key concepts as well as gaps in the way adherence is approached in design, conduct, and reporting of trials for skin self-examination and other self-management practices in people at high risk of melanoma. These findings may usefully guide future trials and clinical practice; evaluation of adherence strategies may be possible using a Study Within A Trial (SWAT) framework within host trials.
According to this recent study, after 2015, overall survival significantly improved for patients with melanoma brain metastasis (MBM), especially with stereotactic radiotherapy and immune checkpoint inhibitors (ICIs). Demonstrating a large survival benefit, ICIs should be considered first after MBM diagnosis, if clinically feasible.