17 October 2024In this review, authors discuss several pivotal tissue-based profiling techniques that can be utilised to identify potential genomic, transcriptomic and immune biomarkers predictive of clinical outcomes following treatment with immune checkpoint inhibitors in melanoma. They also highlight the key opportunities and challenges associated with the use of each of these techniques. The study concludes that the development and implementation of multimodal predictive models which combine data derived from these various methods is the future for achieving precision medicine for patients with melanoma.
15 October 2024Artificial ultraviolet radiation (UVR) is produced during welding and can cause damage to both the eyes (ocular) and the skin (dermal). According to this recent study, there are still many welders and supervisors who do not use adequate protection, despite the well-known acute and chronic effects of exposure to UVR from welding.
15 October 2024According to this recent review, the combination of 5-fluorouracil and calcipotriol effectively treats actinic keratosis by enhancing the immune response and targeting cell overgrowth, while reducing local site reactions and the lengthy treatment time often associated with existing therapies.
15 October 2024This recent study looked at real-world outcomes of immunotherapy for melanoma brain metastases in New Zealand. Most patients were symptomatic and received anti-PD1 monotherapy. Approximately one-third of treated patients are alive at 2 years, but most patients remained symptomatic. This highlights the need for more effective treatment and prospective management of their neurologic rehabilitation needs.
15 October 2024Fianlimab and cemiplimab are high-affinity, human, hinge-stabilized IgG4 monoclonal antibodies, targeting LAG-3 and PD-1, respectively. Results of this recent study show a promising benefit-risk profile of fianlimab/cemiplimab combination for patients with advanced melanoma, including those with previous anti–PD-1 therapy in the adjuvant, but not advanced, setting.
15 October 2024The aim of this study was to identify the available evidence regarding nursing roles in skin cancer screening and early detection and the reported education and training undertaken to do so. The study concludes that with appropriate best practice education, it is within most primary care nurses’ scope of practice to obtain competence in delivering opportunistic skin cancer screening.
19 September 2024This study sought to determine long-term (30-year) survival rates for the 4 American Joint Committee on Cancer 8th edition T categories by analyzing Australian registry data for 210 042 melanoma patients diagnosed from 1982 to 2014.
11 September 2024The objective of this recent study was to consider the causes and magnitude of melanoma overdiagnosis in Australia. Authors also speculate about a possible benefit of overdiagnosis in Australia; namely, a reduction in excess deaths in the geographical areas where melanoma is diagnosed most frequently.
11 September 2024This article discusses advances in imaging and early diagnosis including the use of AI in the field of melanoma diagnosis. It concludes that the benefits of performing biopsies must be balanced with the potential to cause harm. Whole-body imaging can assist with more accurate detection of changing lesions and enable clinicians to focus on lesions where change is detected.
11 September 2024Drug therapies are increasingly used for the treatment of many patients with melanoma. According to this recent review, early referral is crucial, and clinical trials remain the best choice for most patients. Recognition and prompt management of immune-related adverse events (irAEs) is vital, and collaboration between GPs and oncologists is essential for best care.
