According to this recent study, erucin, the major isothiocyanate present in Eruca sativa (commonly known as rocket salads), plays an important role in inhibiting the progression of melanoma and could represent a novel add-on therapy for the treatment of human melanoma.
According to this recent study, aspirin use was associated with a significantly decreased risk of basal cell carcinoma (BCC). While the high incidence and cost of treatment of BCC are demanding both clinically and financially, the low cost of aspirin and its widespread use may have vital implications for its preventative role in this disease.
According to this recent stuy, both treatment methods for superficial basal cell carcinoma - curettage and cryosurgery - showed high clinical clearance rates after one year, whilst curettage reduced the wound healing time.
Results of this recent study indicate that neoadjuvant relatlimab and nivolumab induces a high pathologic complete response rate in resectable melanoma. Safety during neoadjuvant therapy is favourable compared to other combination immunotherapy regimens. These data, in combination with the results of the RELATIVITY-047 trial, provide further confirmation of the efficacy and safety of this new immunotherapy regimen.
Authors of this recent review provide a comprehensive summary of in vitro models, in vivo models, and in silico platforms to study the individual steps of melanoma metastasis. They also highlight the advantages and limitations of each model and discuss the challenges of how to improve current models to enhance translation for melanoma cancer patients and future therapies.
This recent study suggests an association between immune-related adverse events (irAEs) and overall survival for patients with metastatic melanoma, including those treated with combination immune checkpoint blockade (ICB) and those with severe irAEs requiring hospitalization.
This is the first program to upskill dermatologically-trained clinicians to provide genetic testing for familial melanoma. This protocol describes the first clinical trial to compare patient-reported outcomes of genetic testing based on provider type (genetic counsellors vs trained non-genetic clinicians).
This recent study summarizes pertinent information regarding clinical outcomes and the association between patient characteristics and melanoma brain metastases prognosis.
This study aimed to determine the incidence and positivity rate of sentinel nodes (SNs) in the triangular intermuscular space (TIS) of patients with melanoma, and to report their management and patient outcomes. It concludes that lymphoscintigraphy showed TIS SNs in 11% of patients with melanomas on their upper back. In such cases, retrieval of TIS SNs is required for accurate staging and to minimize the risk of TIS recurrence.
The aim of this study was to to evaluate factors associated with 3-year and 5-year OS for patients treated with immune checkpoint inhibitors (ICIs) in advanced solid organ malignancies. Results of the study support the long-term benefits of immunotherapy that in some patients, extend to at least 5 years. Survival is significantly influenced by metastatic site and cancer type.