12 September 2022According to this recent study, electronic tumor-infiltrating lymphocyte (eTIL) % and etTILs scores are robust prognostic markers in patients with primary melanoma and may identify a subgroup of stage II patients at high risk of recurrence who may benefit from adjuvant therapy. Authors of the study also show the molecular correlates behind these scores. Their data support the need for prospective testing of this algorithm in a clinical trial.
8 September 2022Earlier this year the Sunscreen (Product Safety Standard) Act was passed through Parliament. The sunscreen product safety standard (the Standard) will come into force on 8 September 2022. Any sunscreen product manufactured or imported after 8 March 2022 needs to be compliant with the Standard. A sunscreen product cannot be sold if it does not meet the Standard's requirements.
16 August 2022Authors of this recent study evaluated the prognostic value of objective automated electronic tumor-infiltrating lymphocytes (eTILs) quantification to define a subset of melanoma patients with a low risk of relapse after surgical treatment. Results show that eTIL% and etTILs scores are robust prognostic markers in patients with primary melanoma and may identify a subgroup of stage II patients at high risk of recurrence who may benefit from adjuvant therapy.
16 August 2022Preliminary data regarding the upper gastro-intestinal microbiota indicated that Helicobacter pylori seropositivity was associated with a negative prognosis in melanoma patients amenable to ICI. According to this recent study, the negative impact of H. pylori on outcomes seem to be independent from the fecal microbiome composition. These findings warrant further validation and development of therapeutic strategies to eradicate H. pylori in immuno-oncology arena.
13 August 2022Authors of this recent study discovered the potential key signals for occurrence and metastasis of uveal melanoma and provided a theoretical basis for potential clinical application.
13 August 2022According to this recent study, targeting HER2 with agents like afatinib may be a novel therapeutic strategy to treat uveal melanoma and to prevent metastasis.
1 August 2022According to this recent study, recurrence after surgical resection of a first in-transit metastasis (ITM) was common. Patterns of recurrence differed according to anatomical site.
31 July 2022Authors of this review summarize the role of epidermal growth factor receptor (EGFR) signaling in the multidrug resistance of melanomas and discuss possible applications of EGFR inhibitors to overcome the development of drug resistance in melanoma cells during therapy.
30 July 2022According to this recent study, BRAF plus MEK inhibition shows meaningful activity and outcome in patients with advanced melanoma resistant to anti-PD-1-based immunotherapy. Rates of long-term benefit and survival in the study were similar to those reported for treatment-naïve patients receiving first-line MAPKi.
30 July 2022According to this recent study, the rainbow pattern is a dermoscopic sign that can occasionally be observed in invasive malignant melanomas (MMs). In MMs, this feature is usually associated with other dermoscopic criteria of MM and located in a focal and eccentric area, as opposed to a diffuse and isolated presentation in non-MM neoplasms.
