According to this recent study, female patients with advanced melanoma may not benefit as much from combination immune checkpoint inhibitors (ICIs) as male patients would. Tumor mutation burden or estrogen level may serve as an important biomarker associated with ICI response in metastatic melanoma.
Skin cancer is highly preventable, but advocates for prevention initiatives have struggled to gain political traction. This study identifies several strategies that could help raise the political profile for skin cancer prevention in Aotearoa New Zealand.
Although skin cancer is a significant public health issue for New Zealand, it can be largely prevented by reducing excessive exposure to UVR. This study outlines a set of recommendations to help reduce UVR exposure in New Zealand.
Pūrongo Ārai Mate Pukupuku, the Cancer Prevention Report pulls together data, research and recommendations focused on preventing cancer. It assesses actions New Zealand can take to stop cancers developing where possible.
The 'State of the Nation - A Report into Melanoma, A National Health Priority' commissioned by Melanoma Institute Australia (MIA) and Melanoma Patients Australia (MPA) provides a detailed roadmap for reducing the impact of melanoma.
The MelMarT-II trial is a world-wide clinical trial investigating whether there is a difference in disease-free survival for patients treated with either a 1cm or 2cm excision margin for stage II primary cutaneous melanoma.
7-Year Follow-Up of KEYNOTE-006: Pembrolizumab Versus Ipilimumab in Advanced Melanoma presents results of seven years of follow-up of survival for participants enrolled in KEYNOTE-006, including those who consented to transition to the KEYNOTE-587 extension study (NCT03486873).
This retrospective cohort study investigated the risk factors associated with lower extremity lymphedema (LEL) after inguinal lymphadenectomy. It concludes that the number of inguinal lymph nodes removed ≥ 10 was associated with a significantly higher incidence of LEL with a 6.5-fold increased risk in melanoma patients. Female patients were more likely to develop LEL after inguinal lymphadenectomy.
According to this recent study, text messages targeting sun protection are effective in improving sun protection behaviors and reducing sunburn. Results also suggest higher engagement with constant or decreasing message frequency. Interactive messages could also be integrated into sun protection mobile health apps, and provide an opportunity for engaging in health promotion content.
The Auckland Medical Research Foundation is calling for applications for Project Grants to support medical research projects for up to two years duration and a new maximum of $180,000.