Melanoma Institute Australia share new Patient Information Brochures that provide detailed information about common procedures, side effects and exercises to aid recovery.
Based on latest research and best practice advice, Professor David Wilkinson has prepared an outline for the management of melanoma in Australian primary care and skin cancer practices.
This recent study investigated the gut fungal and bacterial composition in early-stage melanoma and correlated microbial profiles with histopathological features. It concludes that gut microbiota composition in early-stage melanoma changes along the gradient from in situ to invasive (and metastatic) melanoma. Changes in the microbiota and mycobiota are correlated to the histological features of early-stage melanoma, and to the clinical course and response to immune therapies of advanced stage melanoma, through a direct or indirect immunomodulation.
This systematic review focuses on the current research investigating the impact of merging information from image features and patient data on the performance of convolutional neural networks (CNN)-based skin cancer image classification. The study indicates the potential benefits of integrating patient data into CNN-based diagnostic algorithms. Further exploratory analyses in this promising field may optimize patient data integration into CNN-based skin cancer diagnostics for patients’ benefits.
The purpose of this recent study was to analyze the inflammationrelated protein cargo of exosomes derived from the serum of primary and metastatic uveal melanoma (UM) patients and healthy donors. The study proposes a panel of exosomal proteins for early detection of UM progression into metastatic disease.
According to this recent study, discontinuation of induction immunotherapy as a result of immune-related adverse events (irAE) did not adversely affect overall survival or time to treatment failure (TTF). irAE observed during ipilimumab and nivolumab induction were associated with improved survival outcomes.
The Royal College of Pathologists of Australasia (RCPA) presents The Pathologists Cut podcast. In their third episode, RCPA President Dr Michael Dray discusses melanoma with RCPA Fellow Professor Richard Scolyer, Co-director at The Melanoma Institute of Australia.
In this recent cohort study, nevi arising on mostly sun-protected acral skin showed a rate of BRAF mutation similar to that of acquired nevi on sun-exposed skin but far higher than that of acral melanoma. These findings are in contrast to the well-characterized mutational landscape of acral melanoma.
Current recommendations regarding the size of local excision (LE) margins for Merkel cell carcinoma (MCC) have not been well established. According to this recent study, the combination of LE clinical margins larger than 1.0 cm and adjuvant radiotherapy was associated with the highest overall survival (OS).
This study concludes that most patients with thin melanomas have an excellent prognosis, but some develop recurrence. It presents nomograms that can accurately identify a subgroup at high risk. An online calculator is available at www.melanomarisk.org.au.