According to this recent study, the American Joint Committee on Cancer (AJCC) eighth edition metastatic (M) category was poorly reflective of prognosis in patients receiving immune checkpoint inhibitors (ICIs). Future staging systems could consider emphasizing the presence of liver metastases and elevated serum lactate dehydrogenase (LDH) levels.
According to this recent study, more than 10% of originally positive sentinel node (SN) biopsies of patients with melanoma concern misclassified nodal nevi. The authors advocate that when adjuvant treatment is considered in patients with stage III melanoma, SN biopsies should be reassessed by an expert melanoma pathologist.
According to this article, with the therapeutic landscape continuing to evolve and newer more complex drug therapies soon to be approved, it is important to recognize the many challenges that patients face and attempt to identify tools and policies that will help to improve treatment outcomes for their melanoma.
This study presents eight cases of melanoma with osteocartilaginous differentiation to highlight its clinical, pathological and molecular features.
This recent review concludes that until optimal surgical margins can be better defined in a randomized trial setting, ideally controlling for melanoma in situ (MIS) subtype and including correlation with histologic excision margins, techniques such as preliminary border mapping of large, ill-defined lesions and, most importantly, sound clinical judgement will be needed when planning surgical clearance margins for the treatment of MIS.
This review summarises novel tumor metabolic pathways and tumor-host metabolic crosstalk mechanisms leading to melanoma progression and drug resistance, with an overview on their translational potential as novel therapeutic targets.
The purpose of this recent study was to analyse long-term trends of cutaneous melanoma (CM) and keratinocyte cancer (KC) in different white populations. The analysis concludes that in white populations, incidence of CM and KC significantly increased. CM incidence continues to rise in the short term but is predicted to decline in future.
According to this recent study, UV photography could identify the areas missed by sun protection lotions with chemical filters.
According to this recent review, strengthening the readiness of non-medical professionals to examine their client's skin offers an opportunity to reduce time to skin cancer diagnosis, improve patient outcomes, and lower healthcare-associated costs of skin cancer treatment.
According to this current perspective, the role of surgery for asymptomatic oligometastatic stage IV melanoma has changed. Patient/tumour factors impact on decision-making (upfront surgery vs immunotherapy), and discussions at specialist melanoma multidisciplinary meetings are recommended.