According to this recent study, inhibition of Integrin beta-like protein 1, a secreted protein, might improve melanoma response to immunotherapies.
Currently, research groups are trying to circumvent the stratum corneum barrier, which limits the penetration of drugs through the skin, by using skin penetration enhancement (SPE) strategies. The SPE strategies investigated include chemical skin penetration enhancers (CPEs), physical skin penetration enhancers (PPEs), nanocarrier systems, and a combination of SPE strategies (cream). Of these, PPEs and cream are the most advanced approaches in terms of preclinical and clinical studies, respectively.
This recent study reviews the clinical presentations of cutaneous immune-related adverse effects associated with checkpoint inhibitor CPI therapy in adult patients with metastatic malignant melanoma.
According to this recent study, vemurafenib modifies the glycans structures and metallomics profile in melanoma cells harboring BRAF mutation that can be further implied in the resistance phenomenon. It opens a new avenue for further studies in the short-term addressing novel targets that hopefully can be used to improve the therapeutic regiment in advanced melanoma patients.
This recent study compared the efficacy and safety of adjuvant nivolumab with other approved treatments using available evidence from randomized controlled trials (RCTs) in a Bayesian network meta-analysis (NMA). It concludes that adjuvant therapy with nivolumab provides an effective treatment option with a promising risk–benefit profile.
The incidence, prevalence, and disability-adjusted life years (DALYs) of skin cancers are increasing disproportionately among different demographic groups. As a worldwide epidemiological assessment, the Global Burden of Disease Study (GBD 2017) provides frequently updated measures of the skin cancer burden, which may help to direct resources and allocate funding to close the gap in global skin cancer disparities.
Nutraceuticals (naturally occurring compounds) were reported to exhibit great efficacy in cancer treatment and prevention. This review overviews skin cancer with its pathogenesis, conventional treatment strategies, and the nano-carrier based approaches for the delivery of nutraceuticals through the skin.
According to this recent study, regular 6- or 12-monthly surveillance imaging using CT or PET/CT has reasonable and consistent sensitivity and specificity over 5-year follow-up for resected stage IIIA–D melanoma patients. These data are useful when discussing the risks and benefits of long-term follow-up.
This recent study examines discrimination and identification of melanoma by using laser-induced breakdown spectroscopy (LIBS) combined with chemometrics methods. It concludes that LIBS combined with chemometric methods for detection and discrimination of human malignancies is a reliable, accurate, and precise technique.
Results of this recent report demonstrate that TPP (triphenylphosphonium) -derivatives selectively induce thiol-dependent metabolic oxidative stress and cell killing in malignant melanoma and support the hypothesis that a hydrogel-based TPP-derivative delivery system could represent a therapeutic drug-delivery strategy for melanoma.