This recent study characterises CMTM6 expression in melanoma and evaluates its association with response to immune checkpoint inhibitors (ICI). The study concludes that CMTM6 expression shows potential as a predictive factor for ICI treatments.
The anti-apoptotic proteins from the Bcl-2 family are important therapeutic targets since they convey resistance to anticancer regimens. According to this recent study, BCL2L10 is expressed in melanoma and contributes to cell survival. Hence, targeting BCL2L10 may enhance the clinical efficacy of other therapies for malignant melanoma.
This recent study investigated the clinical and histopathological features of melanomas diagnosed and treated in an established clinic in Brisbane. It concludes that in Australia, specialised primary care practice plays a major role in detection and treatment of early primary melanoma.
According to this recent study, apoptosis is the only known cell death mechanism induced by UVB irradiation in fibroblasts. Results of the study also showed that lethal UVB irradiation induces a PARP-dependent drastic loss of cellular metabolic activity caused by an overused of NAD+.
Data of this recent study indicate the relevance of serum CD73 in patients with advanced melanoma receiving anti-PD-1 therapy and support further investigation on targeting CD73 in combination with anti-PD-1 antibodies.
The objective of this recent study was to evaluate the proportion and rate of incidental skin cancer detection in urgent skin cancer clinics and investigate the rate of incidental skin cancer detection in 2 groups based on the degree of clinical suspicion of the index lesion for malignancy. The findings support the use of total body skin examination for urgent skin cancer referrals, highlighting the potential harms of solitary lesion assessment in a subgroup.
This recent study compared the preoperative thickness and width of skin cancer by ultrasanography with the measurements by histopathologic findings. It concludes that ultrasonography can accurately measure the width and thickness of skin cancer and predict the safety margins of the wide excision.
The aim of this recent study was to investigate the preventive potential of field-directed repetitive daylight photodynamic therapy for actinic keratoses. It found that repetitive daylight photodynamic therapy had photo-rejuvenating effects. However, the prevention of actinic keratoses by this therapy could not be proven in a statistically reliable manner.
According to this recent study, changes in circulating tumour DNA (ctDNA) can serve as an early indicator of outcomes in metastatic melanoma patients treated with systemic therapies and therefore may serve as a tool to guide treatment decisions.
According to this recent study, AT-rich interactive domain-containing protein 2 (ARID2) is an immunomodulator and a potential biomarker that indicates immune checkpoint inhibitor (ICI) effectiveness in patients with melanoma.