The approach adopted in the face of incomplete excisions of basal cell carcinoma is still controversial. According to this recent study, the presence of compromised margins does not necessarily imply recurrence. Location, tumor size, histological subtype, previous epithelial tumors, and clinical conditions of the patient must be considered when choosing the best treatment option.
Dioscin, which exists in medicinal plants, has potent anticancer effects. However, its effects on skin cancer remain unknown. This recent study investigated the activity and mechanism of dioscin on the human skin cancer A431 cell line. Results of the study suggested that dioscin inhibited skin cancer cell proliferation via adjusting Ataxia telangiectasia‑mutated (ATM)/p53‑mediated cell apoptosis, migration and DNA damage, which should be considered as a potential option for future treatments of skin cancer.
Despite knowledge of subsequent melanoma risk and the benefit of sun protection in risk reduction, melanoma survivors often do not engage in adequate sun protection and continue to sunburn at rates similar to individuals without a history of skin cancer. This novel intensive intervention provided a wearable UV sensor delivering real-time UV exposure with a smartphone and daily text messages. In this short-term study, melanoma survivors managed their daily UV exposure to stay below their maximum tolerated UV dose.
This recent study evaluated the efficacy of Withaferin A (WFA), derived from the medicinal plant Withania Somnifera, as a novel therapeutic agent for the treatment of melanoma. The study concludes that WFA has potent cytopathic effects on melanoma cells through TRIM16, suggesting a potential therapeutic application of WFA in the disease.
According to this recent study, extracellular vesicles (EVs) serve as a non-invasive biomarker to jointly probe tumor-intrinsic and immune changes to immune checkpoint inhibitors (ICI), function as predictive markers of ICI responsiveness, and monitor tumor persistence and immune activation.
According to this recent study, the combination of oncogene AURKB inhibition and PARP inhibitor has a synergistic effect, representing a promising treatment for SKCM.
According to this recent study, the co-delivery of hispolon and doxorubicin could be a promising therapeutic approach to improve clinical outcomes against melanoma.
This recent US study investigated the feasibility and efficacy of online electronic training (e-training) as a way of partnering with non–health care practitioners such as massage therapists (MTs) to reduce the risk of skin cancer. The study concludes that e-training has potential as an intervention in larger trials with MTs for reducing the risk of skin cancer.
According to this recent study, increased infiltration with tumor-infiltrating lymphocytes (TILs) promotes the aggressive behavior and suppresses the immune response of uveal melanoma (UM) cells, thereby inhibiting immunotherapy.
This recent study suggests that miR-524-5p could be considered as a target for the treatment of BRAF inhibitor-resistant melanoma and a prognostic marker in the response of patients to BRAF inhibitors for melanoma.