The purpose of this recent study was to assess whether the introduction of teledermoscopy (TD) in general practice was feasible and might reduce the number of unnecessary referrals to specialists and to assess the diagnostic accuracy and confidence of participating GPs. The study concludes that GPs could benefit from TD to improve their diagnostic accuracy and confidence.
The purpose of this recent study was to to evaluate the management of conjunctival melanoma with local excision and adjuvant brachytherapy. It concludes that local excision with adjuvant brachytherapy provides good tumour control with excellent visual outcome and mild side effects in patients with limited conjunctival melanoma.
Intratumoral (IT) injection of CMP-001, a CpG-A TLR9 agonist packaged within a virus-like particle, is designed to activate tumor-associated plasmacytoid dendritic cells, inducing an interferon-rich tumor microenvironment and anti-tumor CD8+ T cell responses. According to this recent study, IT CMP-001 alone and in combination with pembrolizumab appears well tolerated, can reverse resistance to anti-PD-1 therapy, and can produce deep and durable clinical responses in patients with advanced melanoma.
The aim of this recent study was to investigate the use of radiomics analysis for non-invasive identifcation of BRAF mutation in patients with melanoma brain metastases, based on conventional magnetic resonance imaging (MRI) data. The study concludes that radiomics-based noninvasive genetic characterization is feasible and should be further verifed using large prospective cohorts.
According to this recent study, the interaction between sex and UVI is age dependent. Female sex is an independent risk factor for early-onset melanoma, but female sex also protects against UV-associated melanoma in older age groups.
Secondary lymphoedema in the developed world is most commonly attributed to cancer treatment. The authors of his article review the current data surrounding lymphoedema initiatives, e.g. a prospective screening and a prospective surveillance model (PSM) for early diagnosis and intervention for the prevention and treatment of lymphoedema.
According to this recent study, patients with metastatic melanoma receiving brain-directed radiation therapy with concurrent ipilimumab and nivolumab are at risk for developing severe, surgically refractory radiation necrosis and should be closely followed clinically and with imaging.
This recent study evaluated pembrolizumab plus trametinib for patients with solid tumours or BRAF wild-type melanoma. It concludes that both concurrent or intermittent pembrolizumab plus trametinib dosing were feasible and the combination showed anti tumour activity in patients with advanced solid tumors or advanced BRAF wild-type melanoma.
According to this recent study, combinations of anti-PD-1 with drugs that target the TGFß signaling pathway and/or which reverse melanoma de-differentiation may be effective future therapeutic strategies.
According to this recent study, theory- and evidence-informed public health communications can contribute to improving health-related behaviors. Focusing on the risk of skin cancer may be the most effective strategy to reduce indoor tanning among young white women.