There have been major advances in the understanding of melanoma since the last revision of the World Health Organization (WHO) classification in 2006. This analysis discusses the development of the 9 distinct types of melanoma and distinguishes them by their epidemiology, clinical and histologic morphology, and genomic characteristics.
This paper describes an ongoing research project that aims to elicit the preferences of health care consumers for sun protection via app-based self-monitoring. The results will target technology developers, health care providers, and policy makers, potentially offering some guidance on how to design or use sun-protection-focused self-monitoring apps in ways that are responsive to consumer preferences.
Results of this recent study offer some support for the use of ultraviolet radiation (UVR) meters in areas frequented by adolescents and provide insights into the process issues that are likely to need to be addressed when attempting to trial sun protection interventions in schools.
According to this recent study, low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma.
This recent study investigated the association between blood mercury (Hg) levels and nonmelanoma skin cancer (NMSC). It concludes that higher blood total Mercury (tHg) and methylmercury (MeHg) levels are associated with a higher prevalence of NMSC.
According to this recent study, current algorithm based smartphone apps cannot be relied on to detect all cases of melanoma or other skin cancers.
The MITF and SOX10 transcription factors regulate the expression of genes important for melanoma proliferation, invasion and metastasis. According to this recent study, Disrupted In Renal Carcinoma 3 (DIRC3) may be a clinically important MITF-SOX10 regulated tumour suppressor.
According to this recent study, there is a crosstalk between lipogenesis and mitochondrial function in tumor biology. The study highlights targeting ATP-citrate lyase (ACLY) as a potent therapeutic approach via simultaneously impairing tumor growth and MAPK inhibition resistance in melanoma.
This recent study investigated if targeting receptor tyrosine kinase AXL together with DNA damage response proteins would be therapeutically beneficial. It concludes that this could be a promising treatment strategy in melanoma. Further investigations in patient groups lacking treatment alternatives should be pursued.
Internal pathology review (IPR) of invasive melanoma leads to both changes in staging and the surgical management of melanoma and should remain an important component of care of melanoma patients at a tertiary referral center.