News and Events

Nivolumab a more efficacious adjuvant treatment for patients with resected high-risk melanoma than ipilimumab

24 September 2020

This recent report provides four year efficacy, initial overall survival, and late-emergent safety results of the CheckMate 238 phase 3 adjuvant trial in patients with resected stage IIIB-C or stage IV melanoma. Results show nivolumab is an efficacious adjuvant treatment for patients with resected high-risk melanoma, with a safety profile that is more tolerable than that of ipilimumab.

Use of combinatorial treatment approach would delay the emergence of resistance to targeted therapy in melanoma patients

22 September 2020

This study reviews known and emerging molecular mechanisms that underlay the development of resistance to MAPK inhibition in melanoma cells and discusses potential strategies to overcome these mechanisms. It found resistance to targeted therapy is underpinned by early functional adaptations involving the rewiring of cell states and metabolic pathways and the use of a combinatorial treatment approach would delay the emergence of resistance and improve patient outcomes.

UV sensors may improve use of sunscreen and sunglasses in adolescents

22 September 2020

This recent Australian study tested wearable UV sensors as a means of improving sun protection in young adults at an outdoor festival. It found that those provided with the sensor improved their use of sunglasses and sunscreen, with participants reporting it a useful tool to remind them to use sun protection.

Skin cancer survivors apply sunscreen in line with recommended guidelines

19 September 2020

This recent study analysed sunscreen application technique amongst patients with a history of skin cancer. It found skin cancer survivors of both genders effectively applied sunscreen in line with recommended quantity guidelines, but men were significantly better at protecting their ears.

Risk to develop BCC in high UV-exposed skin double that of low UV exposure independent of histological subtype, tumor localization and Fitzpatrick phototype

15 September 2020

This recent study evaluated the influence of histological subtype, tumor localization and Fitzpatrick phototype on the risk to develop basal cell carcinoma in highly UV-exposed cases and controls compared to those with moderate or low solar UV exposure. It found the risk to develop basal cell carcinoma in highly occupationally UV-exposed skin was doubled consistently, independent of histological subtype, tumor localization and Fitzpatrick phototype.