COVID‐19 pandemic contributed to delayed melanoma diagnoses and shift towards more advanced disease at presentation
Background:
The COVID‐19 pandemic has significantly disrupted global healthcare systems. Melanoma, a highly aggressive skin cancer whose prognosis is closely tied to early detection, has been particularly impacted. Lockdowns, changes to healthcare resource reallocation and patient hesitancy in seeking care have all contributed to delays in melanoma diagnoses and treatment modifications. Understanding the extent of this disruption is crucial to inform future healthcare planning during global crises.
Objectives:
To evaluate the impact of the COVID‐19 pandemic on melanoma incidence, diagnostic delays and disease severity by comparing findings from pre‐pandemic and pandemic periods through a systematic review of existing literature.
Methods:
A systematic search was conducted across PubMed, Scopus, Web of Science and Cochrane Library in September 2024, adhering to PRISMA guidelines. Eligible studies included clinical trials, observational studies, reviews and case series that reported melanoma incidence, diagnostic delays or changes in treatment between pre‐COVID‐19 (2015−2019) and COVID‐19/ post‐COVID‐19 (2019−2024) periods. Data extraction focused on incidence rates, Breslow thickness, ulceration, treatment changes and patient outcomes. Study quality was assessed using the Newcastle−Ottawa Scale and Joanna Briggs Institute tools.
Results:
Out of 503 studies screened, 55 met the inclusion criteria. Most studies reported a decline in diagnosed melanoma cases during the pandemic, accompanied by an increase in Breslow thickness and ulceration rates, indicating delayed presentations and more advanced disease. Significant disruptions in treatment pathways, including reduced surgical excisions,were frequently noted.
Conclusions:
The COVID‐19 pandemic contributed to delayed melanoma diagnoses and a shift towards more advanced disease
at presentation. These findings highlight the critical need for resilient cancer care systems to maintain timely diagnostic and treatment services during future public health emergencies.
Source:
Soni, A., Purcell, E., Lim, B., Marcaccini, G., Seth, I., & Rozen, W. M. (2025). The silent spread: A systematic review of delayed melanoma diagnosis and disease progression during the COVID‐19 pandemic. JEADV Clinical Practice. https://doi.org/10.1002/jvc2.70154