Category: Research
Melanoma Care Program to help early-stage melanoma patients manage fear of recurrence maintained effectiveness at 6- and 12-month follow-up
Purpose: To investigate the effectiveness of the Melanoma Care Program, an evidence-based, psychological intervention delivered through a stepped-care model, to address fear of cancer recurrence (FCR)…
Protocol for a microsimulation model of risk-tailored melanoma screening
In populations of European descent, melanoma is a high burden cancer in terms of incidence and healthcare costs, with early detection linked to better prognosis. There is no organised population scree…
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Phase 3 randomized clinical trial: Both radiotherapy and imiquimod are efficient and well-tolerated treatments for lentigo maligna
Background: For patients with lentigo maligna who are not suitable for surgery, radiotherapy, or topical imiquimod are alternative nonsurgical treatments. Objective: This trial aimed to assess the ef…
Presence of white scales and keratin might guide accurate recognition of invasive SCC
Background: In people with lighter skin phototypes, squamous cell carcinoma (SCC) is typically nonpigmented and must be distinguished from other nonpigmented tumours. Although the dermoscopic features…
BO-112 plus pembrolizumab for patients with anti–PD-1–resistant advanced melanoma: Phase II clinical trial SPOTLIGHT-203
Purpose: Patients with anti–PD-1–resistant melanoma (MEL) have no well-defined standard of care. BO-112 is a synthetic, double-stranded RNA (poly I:C) nanoplexed with polyethylenimine that when admini…
Cumulative lifetime UVA exposure may be an underappreciated contributor to BCC and SCC risk
Background: Few epidemiological studies have distinguished the effects of solar ultraviolet (UV) radiation (UVR) wavelength, including UVB and UVA, on the risk of basal cell carcinoma (BCC) and squamo…
Long-term follow-up of real-world adjuvant anti–PD-1 checkpoint inhibition and targeted therapy in patients with stage III melanoma
Purpose: Adjuvant treatment with immune checkpoint inhibition (PD-1) and targeted therapy (TT) with BRAF + MEK inhibitors significantly improved recurrence-free survival (RFS) of patients with stage I…
Halving of Australian children’s naevus counts during 1992–2016 and change in sun behaviour
Background: The lifetime risk of cutaneous melanoma in Australia is the highest in the world. The most important melanoma risk factor is the number of acquired cutaneous melanocytic naevi (AMN) on a p…
Incidence and associated risk factors of skin cancers in renal transplant recipients in Canterbury
Background: Skin cancer is a significant complication amongst renal transplant recipients, associated with substantial morbidity and mortality. Aim: This retrospective observational study aimed to as…
Tanning bed radiation induces melanoma by increasing mutation burden of melanocytes and by mutagenizing a broader field of melanocytes
Tanning bed users have a significantly increased risk of melanoma, but it remains unclear how indoor tanning drives melanomagenesis. To better understand the etiology of melanoma associated with tanni…