Category: Research
Phase 3 randomized clinical trial: Both radiotherapy and imiquimod are efficient and well-tolerated treatments for lentigo maligna
Background: For patients with lentigo maligna who are not suitable for surgery, radiotherapy, or topical imiquimod are alternative nonsurgical treatments. Objective: This trial aimed to assess the ef…
Presence of white scales and keratin might guide accurate recognition of invasive SCC
Background: In people with lighter skin phototypes, squamous cell carcinoma (SCC) is typically nonpigmented and must be distinguished from other nonpigmented tumours. Although the dermoscopic features…
BO-112 plus pembrolizumab for patients with anti–PD-1–resistant advanced melanoma: Phase II clinical trial SPOTLIGHT-203
Purpose: Patients with anti–PD-1–resistant melanoma (MEL) have no well-defined standard of care. BO-112 is a synthetic, double-stranded RNA (poly I:C) nanoplexed with polyethylenimine that when admini…
Cumulative lifetime UVA exposure may be an underappreciated contributor to BCC and SCC risk
Background: Few epidemiological studies have distinguished the effects of solar ultraviolet (UV) radiation (UVR) wavelength, including UVB and UVA, on the risk of basal cell carcinoma (BCC) and squamo…
Long-term follow-up of real-world adjuvant anti–PD-1 checkpoint inhibition and targeted therapy in patients with stage III melanoma
Purpose: Adjuvant treatment with immune checkpoint inhibition (PD-1) and targeted therapy (TT) with BRAF + MEK inhibitors significantly improved recurrence-free survival (RFS) of patients with stage I…
Halving of Australian children’s naevus counts during 1992–2016 and change in sun behaviour
Background: The lifetime risk of cutaneous melanoma in Australia is the highest in the world. The most important melanoma risk factor is the number of acquired cutaneous melanocytic naevi (AMN) on a p…
Incidence and associated risk factors of skin cancers in renal transplant recipients in Canterbury
Background: Skin cancer is a significant complication amongst renal transplant recipients, associated with substantial morbidity and mortality. Aim: This retrospective observational study aimed to as…
Tanning bed radiation induces melanoma by increasing mutation burden of melanocytes and by mutagenizing a broader field of melanocytes
Tanning bed users have a significantly increased risk of melanoma, but it remains unclear how indoor tanning drives melanomagenesis. To better understand the etiology of melanoma associated with tanni…
Polymer nanofiber-based electrodes for tyrosinase detection in melanoma diagnosis: scalable, cost-effective melanoma screening
The rising global incidence of melanoma and its high mortality rates due to late diagnosis demand rapid, sensitive, and non-invasive diagnostic tools. Here, we introduce a disposable electrochemical b…
Dermatoscopy may offer valuable prognostic insights into melanoma’s biological behavior before excision and help guide therapeutic decisions
Current melanoma prognostic tools have limited clinical use at the bedside, highlighting the need for more effective biomarkers. Dermatoscopy correlates with established prognostic markers obtained th…