Category: Research
Early nicotinamide use reduces risk of aggressive skin cancers
Importance: Nicotinamide supplementation has been studied as a chemopreventive medication for reducing skin cancer risk, but large-scale data are limited. Objective: To determine the clinical effica…
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Interlaboratory variability of SPF results is considerable and likely greater than expected
Objective: Determination of the sunburn protection provided by a sunscreen product is required globally for sales of these products. Over the past 80 years, many aspects of determining the protection…
Management of Skin Toxicities in Cancer Treatment: An Australian/New Zealand Perspective
Cancer systemic therapeutics and radiotherapy are often associated with dermatological toxicities that may reduce patients’ quality of life and impact their course of cancer treatment. These toxiciti…
Pre- and post-treatment care for actinic keratoses: An Australian and New Zealand perspective
Background: Actinic keratoses (AKs), also known as solar keratoses, are precancerous skin lesions that typically occur following long-term exposure to ultraviolet radiation. AKs can evolve into cutane…
Cutaneous melanoma management — Update and narrative review for the General Surgeon
Background and Aims: The multidisciplinary management of cutaneous melanoma is advancing rapidly. Surgeons remain a key entry point for melanoma patients into specialist care and their up-to-date kno…
Dynamic recurrence risk prediction tool for adjuvant therapy in stage III melanoma empowering informed decision-making
Background: Prognosis for AJCC stage III melanoma varies significantly. Adjuvant therapies, including pembrolizumab, nivolumab, and dabrafenib/trametinib, have markedly reduced recurrence risk, as sho…
Regular sunscreen users may need supplementary vitamin D
Background: Sunscreen reduces vitamin D production in experimental studies. It is uncertain whether this translates to ‘real-world’ settings. Objectives: We aimed to dtermine if routinely applying hi…
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Is wide local excision after primary excision of melanoma in situ unnecessary?
Dessinioti and coauthors1 present a retrospective study undertaken in Greece reporting the clinical outcomes for 401 people diagnosed and treated for melanoma in situ from 1991 to 2023 at a major mela…
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Sentinel lymph node biopsy review: historical trajectory, current guidelines and controversies, future directions
Sentinel lymph node biopsy (SLNB) has transformed the management of cutaneous melanoma, emerging as a cornerstone in evaluating regional lymphatic spread while minimizing surgical morbidity. From its …
Higher serum 25(OH)D levels associated with increased skin cancer risk, likely reflecting cumulative UV exposure
Background and objectives: Skin cancer, the most common global malignancy, is linked to ultraviolet (UV)-driven serum 25-hydroxyvitamin D (25(OH)D)synthesis, with its controversial role possibly refle…