Category: Research
Immune checkpoint inhibition in metastatic or non-resectable melanoma after failure of adjuvant anti-PD-1 treatment
Background: Adjuvant immune checkpoint inhibition (ICI) with anti-PD-1 antibodies in high-risk resected melanoma has been shown to improve recurrence-free survival. It is unclear whether prior adjuvan…
Melanoma in England: incidence is up, mortality is down
In recent decades, the epidemiology of cutaneous melanoma has undergone profound changes in many populations around the world, with steep rises in incidence set against recent declines in mortality. I…
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Prognostic and predictive value of IDO expression in metastatic melanoma treated with Ipilimumab
Background: The tumor microenvironment is crucial for prognosis and response to immunotherapy in several tumor entities. Methods: In a multicenter retrospective study, a total of 86 tumor samples f…
Training lifeguards to assist in skin cancer prevention
Lifeguards play a crucial role in ensuring water safety, but they also are uniquely positioned to promote skin cancer prevention and proper sunscreen use.1,2 There are several benefits and challenges …
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Recent advances in epigenetic mechanisms in melanoma development and progression
Knowledge of cancer development and progression gained over the last few decades has enabled mapping of genetic and epigenetic changes unique to different phases of tumor evolution. Here we focus on e…
Significant increase in mesenteric panniculitis development following BRAFi/MEKi treatment compared to ICI in patients with melanoma
Objectives: BRAF/MEK inhibitors (BRAFi/MEKi) and PD-1 and CTLA-4 immune checkpoint inhibitors (ICI) have revolutionized malignant melanoma treatment and improved patients’ clinical outcome significan…
Rechallenge of ipilimumab and nivolumab in advanced melanoma patients after previous ipilimumab-based therapy had a considerable response rate, acceptable safety profile, and potential for a durable response
Background: Ipilimumab+nivolumab (IPINIVO) can induce durable responses in advanced melanoma, but many patients experience progression at some point. It is currently unknown to what extent these pati…
Histological deep margins in cutaneous squamous cell carcinoma of the scalp and risk of recurrence
Background: Consensus is lacking on adequate deep histological margins in cutaneous squamous cell carcinoma (cSCC). Deep clearance for tumours located on the scalp is limited by anatomic constraints. …
Self-assessed improved sun protection after diagnosis of melanoma is associated with improved survival
Background: Although ultraviolet radiation is the most important risk factor for skin cancer in general, its role in disease control after the diagnosis of melanoma remains to be elucidated. Objectiv…
Enhancing skin cancer prevention and awareness in the Italian population: Insights from the “Save Your Skin” screening campaign
Introduction: Skin cancer prevention campaigns aim to reduce modifiable risk factors, yet high-risk groups often maintain inadequate protection practices. Objectives: This study analyzed data from …