Category: Research
Individualised mRNA vaccines for melanoma: current status and outlook
Immunotherapy, consisting mainly of immune checkpoint inhibitors, has been successfully employed in the treatment of early and advanced-stage melanoma for more than ten years. Personalized mRNA vaccin…
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Lessons from neoadjuvant immunotherapy in melanoma: understanding antitumour immunity and tumour escape
Immunotherapy has become a fourth pillar of cancer therapy, alongside surgery, radiotherapy and chemotherapy. Cancer immunotherapy seems to be most effective in the context of low but not negligible t…
Effective sunscreen application: changes to labelling regulation required to ensure consumers receive clear, accurate and consistent information
Objective: To explore consumer understanding of regulated claims and expert recommendations for effective sunscreen application. Methods: We used a Pragmatic Qualitative Research Design to explore su…
Need for a coordinated global response to climate change and its impact on skin cancer
Climate change is increasingly recognized as a major public health challenge with wide-ranging effects on health conditions, including skin cancer. Rising global temperatures and heightened ultraviole…
Early nicotinamide use reduces risk of aggressive skin cancers
Importance: Nicotinamide supplementation has been studied as a chemopreventive medication for reducing skin cancer risk, but large-scale data are limited. Objective: To determine the clinical effica…
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Interlaboratory variability of SPF results is considerable and likely greater than expected
Objective: Determination of the sunburn protection provided by a sunscreen product is required globally for sales of these products. Over the past 80 years, many aspects of determining the protection…
Management of Skin Toxicities in Cancer Treatment: An Australian/New Zealand Perspective
Cancer systemic therapeutics and radiotherapy are often associated with dermatological toxicities that may reduce patients’ quality of life and impact their course of cancer treatment. These toxiciti…
Pre- and post-treatment care for actinic keratoses: An Australian and New Zealand perspective
Background: Actinic keratoses (AKs), also known as solar keratoses, are precancerous skin lesions that typically occur following long-term exposure to ultraviolet radiation. AKs can evolve into cutane…
Cutaneous melanoma management — Update and narrative review for the General Surgeon
Background and Aims: The multidisciplinary management of cutaneous melanoma is advancing rapidly. Surgeons remain a key entry point for melanoma patients into specialist care and their up-to-date kno…
Dynamic recurrence risk prediction tool for adjuvant therapy in stage III melanoma empowering informed decision-making
Background: Prognosis for AJCC stage III melanoma varies significantly. Adjuvant therapies, including pembrolizumab, nivolumab, and dabrafenib/trametinib, have markedly reduced recurrence risk, as sho…