Category: Research
Administration of nivolumab plus ipilimumab: Infusion of the fixed‐ratio combination versus sequential infusions in two randomized controlled trials of metastatic melanoma (CheckMate 742) and renal cell carcinoma (CheckMate 800)
Background: Immune checkpoint inhibitors can be coadministered as a fixed‐ratio combination (FRC) or administered as sequential infusions (ASI). Two randomized, open‐label trials compared nivolumab þ…
Longitudinal cohort study: Nearly half of patients treated for skin cancer will develop at least one more
Background: Many patients will develop more than one skin cancer; however, most research to date has examined only case status. Objective: Describe the frequency and timing of the treatment of multip…
Dissecting response to neoadjuvant immunotherapy-treated melanoma using cancer-immunity cycle-associated signatures
Neoadjuvant combination therapy with anti-PD-1 and anti-CTLA4 agents has significantly improved long-term survival in patients with metastatic melanoma, yet not all patients respond to treatment. Resp…
Mitochondrial proteome landscape unveils key insights into melanoma severity and treatment strategies
Background: Melanoma, the deadliest form of skin cancer, exhibits resistance to conventional therapies, particularly in advanced and metastatic stages. Mitochondrial pathways, including oxidative phos…
Treatment with encorafenib plus binimetinib study: brain metastasis response rate of over 60% in patients with unresectable metastatic BRAF V600-mutant melanoma with brain metastases
POLARIS was a study to evaluate different doses of encorafenib plus binimetinib for people with BRAF V600-mutant melanoma with brain metastasis. The first part, known as the safety lead-in, looked at …
Margins in head and neck non-melanoma skin cancer surgery: clinical/pathological criteria and their impact on oncological outcomes and therapeutic choices
Introduction: Non-melanoma skin cancers (NMSCs), including basal (BCC) and squamous cell carcinoma (SCC), are the most prevalent malignancies affecting the skin, with the head and neck region being th…
Older population is facing a substantial growing burden of skin cancer
Importance: Skin cancer is a significant public health threat in the aging population, yet data on its burden and trends are limited. Objective: To evaluate the global burden of skin cancer among…
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EGFR overexpression emerges as potential predictive biomarker for responsiveness to second-line ICIs in BRAFi/MEKi-resistant melanoma
Background: Resistance to BRAF and MEK inhibitors (BRAFi/MEKi) in metastatic melanoma frequently results in cross-resistance to immune checkpoint inhibitors (ICI), limiting effective treatment option…
Toolbox for prevention of skin cancer among outdoor workers led to reduction of internal UVR exposure, consistent with self-reported increase in sunscreen use
Introduction: Due to ultraviolet radiation (UVR) exposure at work, outdoor workers face a higher risk of keratinocyte carcinoma (KC) than indoor workers. This study evaluates the short-term effective…
Sun safety policy implementation in Aotearoa New Zealand: current landscape and progress
Skin cancer is a critical public health issue in Aotearoa New Zealand (A/NZ), with alarming incidence rates and substantial economic costs. Excessive solar ultraviolet radiation is the primary modifia…