Category: Research
The epiMelanoma test enables plasma-based detection of melanoma and prediction of immunotherapy response
Background: Melanoma is one of the most serious skin cancers worldwide, often progressing without obvious symptoms. Early detection is crucial to enable timely intervention, reducing morbidity and mor…
Systematic review of molecular basis of BRAF inhibitor resistance in melanoma
Background: Melanoma, the deadliest human skin cancer, frequently harbors activating BRAF mutations, with V600E being the most prevalent. These alterations drive constitutive activation of the MAPK p…
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COVID‐19 pandemic contributed to delayed melanoma diagnoses and shift towards more advanced disease at presentation
Background: The COVID‐19 pandemic has significantly disrupted global healthcare systems. Melanoma, a highly aggressive skin cancer whose prognosis is closely tied to early detection, has been particu…
Comparison between cutaneous, mucosal, acral, nail, and ocular melanoma malignancy
A melanoma is a malignant neoplasm that originates from melanocytes. Melanocytes are found in various body sites—they are most commonly found in the skin (including acral sites and nail units), ocular…
A diagnosis of dysplastic naevus has no clinical relevance and unnecessarily confounds therapeutic decision-making
The term ‘dysplastic naevus’ first introduced in 1980, has since engendered considerable debate regarding its ontological legitimacy, the appropriateness of its nomenclature, and its potential prognos…
Low triglyceride levels are associated with increased risk of immune-related adverse events in patients receiving immune checkpoint inhibitors
Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy by enhancing anti-tumor immune responses, yet their use can lead to immune-related adverse events (irAE), including neurological c…
Solid phase micro extraction of volatile organic compounds (VOC) shows promise for future study of V
Introduction: Skin cancer sites are known to release volatile organic compounds (VOCs) and these compounds can be collected and analysed to aid in the chemical profiling of skin cancers. Patients an…
Benefits of spectral CT imaging for assessment of metastases in melanoma patients dependent on assessed tissue
Background: Pilot studies have indicated diagnostic benefits from using dual-energy CT (DECT) for staging and follow-up of melanoma patients. The purpose of this study was to investigate the sensitiv…
C5aR1 promotes invasion, metastasis, and poor prognosis in cSCC
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and the metastatic from is associated with a poor prognosis. Here, the role of the complement C5a receptor C5aR1 was…
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Cancer vaccine trials in advanced melanoma show promising efficacy
Background: The emergence of checkpoint inhibitors (CPIs) has significantly improved survival outcomes in later-stage melanoma. However, the efficacy of these treatments remains limited, with around …
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