Category: Research
Novel patient-derived primary cell line MelT79 represents valuable model for understanding cutaneous melanoma heterogeneity, progression, and resistance mechanisms
Introduction: Cutaneous melanoma (CM) is an aggressive form of skin cancer, with rising incidence and poor prognosis at advanced stages. While early-stage CM typically carries a favorable prognosis, a…
Wide local excision beyond the subcutaneous fat not associated with survival benefit of acral melanoma of the sole
Background: Preservation of plantar subcutaneous fat is crucial for cushioning in the surgical treatment of acral melanoma of the sole. However, no studies exist on the relationship between deep marg…
Review: global trends in melanoma incidence and mortality, effects of screening programs, consequences of overdiagnosis
Melanoma incidence has increased over recent decades, yet mortality has been relatively stable. This pattern has raised concern that many newly diagnosed melanomas, particularly melanoma in situ, may …
Elevated emotional distress before tumor-infiltrating lymphocytes therapy is associated with reduced therapeutic outcomes
Aims: Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TILs) has demonstrated benefit for patients with advanced melanoma refractory to first-line immune checkpoint inhibitors (ICIs).…
Specific gut microbial taxa and immune-related gene expression patterns may be associated with differential responses to BRAF/MEK-targeted therapy in metastatic melanoma
Gut microbiota has been associated with carcinogenesis and immune regulation. While there is evidence supporting its influence on immunotherapy response in melanoma, its impact on BRAF/MEK-targeted th…
Distinct risk factor profiles for nevus-associated and de novo melanomas, particularly polygenic risk and nevus propensity
Importance: No prospective epidemiologic studies have investigated genetic vs environmental factors on the risks of nevus-associated melanoma (NAM) and de novo melanoma. Objective: To determine whe…
AI-driven tumor-infiltrating lymphocytes quantification tool may provide consistent, reliable assessments with strong potential for clinical integration into melanoma management
Importance: Tumor-infiltrating lymphocytes (TILs) are a provocative biomarker in melanoma, influencing diagnosis, prognosis, and immunotherapy outcomes; however, traditional pathologist-read TIL ass…
Administration of nivolumab plus ipilimumab: Infusion of the fixed‐ratio combination versus sequential infusions in two randomized controlled trials of metastatic melanoma (CheckMate 742) and renal cell carcinoma (CheckMate 800)
Background: Immune checkpoint inhibitors can be coadministered as a fixed‐ratio combination (FRC) or administered as sequential infusions (ASI). Two randomized, open‐label trials compared nivolumab þ…
Longitudinal cohort study: Nearly half of patients treated for skin cancer will develop at least one more
Background: Many patients will develop more than one skin cancer; however, most research to date has examined only case status. Objective: Describe the frequency and timing of the treatment of multip…
Dissecting response to neoadjuvant immunotherapy-treated melanoma using cancer-immunity cycle-associated signatures
Neoadjuvant combination therapy with anti-PD-1 and anti-CTLA4 agents has significantly improved long-term survival in patients with metastatic melanoma, yet not all patients respond to treatment. Resp…