Category: Research
Training lifeguards to assist in skin cancer prevention
Lifeguards play a crucial role in ensuring water safety, but they also are uniquely positioned to promote skin cancer prevention and proper sunscreen use.1,2 There are several benefits and challenges …
Read more about 'Training lifeguards to assist in skin cancer prevention'...
Recent advances in epigenetic mechanisms in melanoma development and progression
Knowledge of cancer development and progression gained over the last few decades has enabled mapping of genetic and epigenetic changes unique to different phases of tumor evolution. Here we focus on e…
Significant increase in mesenteric panniculitis development following BRAFi/MEKi treatment compared to ICI in patients with melanoma
Objectives: BRAF/MEK inhibitors (BRAFi/MEKi) and PD-1 and CTLA-4 immune checkpoint inhibitors (ICI) have revolutionized malignant melanoma treatment and improved patients’ clinical outcome significan…
Rechallenge of ipilimumab and nivolumab in advanced melanoma patients after previous ipilimumab-based therapy had a considerable response rate, acceptable safety profile, and potential for a durable response
Background: Ipilimumab+nivolumab (IPINIVO) can induce durable responses in advanced melanoma, but many patients experience progression at some point. It is currently unknown to what extent these pati…
Histological deep margins in cutaneous squamous cell carcinoma of the scalp and risk of recurrence
Background: Consensus is lacking on adequate deep histological margins in cutaneous squamous cell carcinoma (cSCC). Deep clearance for tumours located on the scalp is limited by anatomic constraints. …
Self-assessed improved sun protection after diagnosis of melanoma is associated with improved survival
Background: Although ultraviolet radiation is the most important risk factor for skin cancer in general, its role in disease control after the diagnosis of melanoma remains to be elucidated. Objectiv…
Enhancing skin cancer prevention and awareness in the Italian population: Insights from the “Save Your Skin” screening campaign
Introduction: Skin cancer prevention campaigns aim to reduce modifiable risk factors, yet high-risk groups often maintain inadequate protection practices. Objectives: This study analyzed data from …
Majority of patients with melanoma experience substantial atherosclerotic plaque growth during ICI therapy
Background: Immune checkpoint inhibitors (ICIs) are effective anticancer agents but significantly increase cardiovascular risk. This could be due to its potential to induce or worsen atherosclerosis.…
Genetic test for skin cancer shows potential for accelerating early personalized chemoprevention in ultra-high risk transplant patients
Background: Transplant patients are at extreme risk of multiple invasive skin cancers. Chemopreventive medication can reduce this risk by ∼50%, but clinicians are unable to identify high-risk patient…
Neoadjuvant treatment with cobimetinib and atezolizumab±vemurafenib associated with low rate of distant metastasis in patients with high-risk stage III melanoma
Background: Neoadjuvant treatment has become standard for patients with high-risk operable stage III melanoma, but the optimal regimen is unknown. Targeted therapy approaches yield high pathological …