Category: Research
Serum metabolome serves as diagnostic biomarker and discriminates patients with melanoma from healthy individuals
Melanoma is a deadly cancer with increasing incidence and mortality rates, and biomarkers for diagnosis are urgently needed. The impact of the microbiome, genetic factors, and immunologic markers on d…
Review of immune checkpoint inhibitors in non-melanoma malignancies
Over the last decade, immune checkpoint inhibitors (ICIs) have been established as an integral component of the contemporary anticancer armamentarium. In dermatology, ICIs are most established as trea…
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CtDNA detection after surgery can identify melanoma patients with worse prognosis
Background: Locally advanced melanoma has a variable prognosis. Currently, there are no reliable criteria to stratify the risk of disease relapse and identify those patients who will benefit the most …
Therapeutic approaches to mucosal melanoma
Mucosal melanoma (MM) is a rare and aggressive subtype of melanoma arising from mucosal tissues, with distinct genomic and clinical characteristics compared with cutaneous melanoma (CM). Despite thera…
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Novel patient-derived primary cell line MelT79 represents valuable model for understanding cutaneous melanoma heterogeneity, progression, and resistance mechanisms
Introduction: Cutaneous melanoma (CM) is an aggressive form of skin cancer, with rising incidence and poor prognosis at advanced stages. While early-stage CM typically carries a favorable prognosis, a…
Wide local excision beyond the subcutaneous fat not associated with survival benefit of acral melanoma of the sole
Background: Preservation of plantar subcutaneous fat is crucial for cushioning in the surgical treatment of acral melanoma of the sole. However, no studies exist on the relationship between deep marg…
Review: global trends in melanoma incidence and mortality, effects of screening programs, consequences of overdiagnosis
Melanoma incidence has increased over recent decades, yet mortality has been relatively stable. This pattern has raised concern that many newly diagnosed melanomas, particularly melanoma in situ, may …
Elevated emotional distress before tumor-infiltrating lymphocytes therapy is associated with reduced therapeutic outcomes
Aims: Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TILs) has demonstrated benefit for patients with advanced melanoma refractory to first-line immune checkpoint inhibitors (ICIs).…
Specific gut microbial taxa and immune-related gene expression patterns may be associated with differential responses to BRAF/MEK-targeted therapy in metastatic melanoma
Gut microbiota has been associated with carcinogenesis and immune regulation. While there is evidence supporting its influence on immunotherapy response in melanoma, its impact on BRAF/MEK-targeted th…
Distinct risk factor profiles for nevus-associated and de novo melanomas, particularly polygenic risk and nevus propensity
Importance: No prospective epidemiologic studies have investigated genetic vs environmental factors on the risks of nevus-associated melanoma (NAM) and de novo melanoma. Objective: To determine whe…