Category: Research
Nurse-led models of service delivery for skin cancer detection demonstrate potential for high diagnostic accuracy, effective treatment delivery and enhanced patient education on skin self-examination
Aim: To consolidate evidence on nurse-led models for skin cancer detection by focusing on their roles, comparing their effectiveness to physician-led care and highlighting any value-added benefits. D…
FDG-PET associations with pathological response and survival with neoadjuvant immunotherapy for melanoma
Background: Neoadjuvant immunotherapy has become the new standard of care for stage III melanoma. This study sought to describe the metabolic changes seen with fludeoxyglucose-18-positron emission to…
Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment
MicroRNAs (miRNAs) hold significant promise as circulating cancer biomarkers and unlike many other molecular markers, they can provide valuable insights that extend beyond tumour biology. The expressi…
3D total-body photography in patients at high risk for melanoma: randomized clinical trial
Importance: Three-dimensional (3D) total-body photography (TBP) can support clinicians in monitoring and identifying changes to skin lesions in patients at high risk of melanoma. Objective: To as…
Cost-effectiveness analysis of 3D total-body photography for people at high risk of melanoma
Importance: Greater use of novel digital technologies could be associated with improved health outcomes and save health care costs by detecting smaller melanomas earlier (needing less treatment) or b…
Specific pathways and marker genes in peripheral CD4+T-cells may predetermine melanoma staging and immunotherapy resistance
Background and purpose: Promoting adaptive immunity with ICIs has drastically improved melanoma prognosis, but not for all patients. Some cases relapse in the first few months, while others keep dura…
Patients with resected stage IIB/C melanoma treated with adjuvant nivolumab demonstrated stable health-related quality of life, minimal bother from side effects
Background: In the phase 3 CheckMate 76 K trial, adjuvant nivolumab significantly improved recurrence-free survival and distant metastasis-free survival versus placebo in patients with resected stage …
Significant reduction in surgical interventions for melanoma in upcoming years
Melanoma surgery has evolved from elective lymph node dissection (ELND) to sentinel lymph node biopsy (SLNB) and wide local excision (WLE) margins have come down from 5 cm to nowadays 1 – 2 cm. Recent…
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Real-life cohort of patients with resected high-risk melanoma treated by adjuvant anti-PD1 therapy: nearly half of patients underwent recurrences, RFS at 24 months was 64%
Background: Programmed cell death protein-1 (PD1) antibodies are currently the standard treatment for resected high-risk melanoma, yet recurrence rate remains high. Objectives: This real-life observa…
Benefits of photoprotection should be taught early to children, caregivers, and parents of all skin tones
Background: Early childhood sun exposure contributes to lifetime risk of skin cancer. Many individuals from diverse ethnic backgrounds believe their skin tone confers immunity to sun damage; however,…