Category: Research
Predictive factors for development of in-transit metastasis in patients with melanoma
Background: In patients with melanoma, in-transit metastasis (ITM) can develop. This study aimed to identify the risk for a first recurrence of ITM and associated predictive clinical factors in a larg…
ZEB1-mediated regulation of PD-L1 tumor expression could contribute to immune escape in melanoma
Tumor cells can evade antitumor immune response by expressing the PD-L1 ligand, leading to the inhibition of PD-1-expressing T lymphocytes. The mechanisms that regulate PD-L1 expression in cancer cell…
Study on sun exposure and associated risks in the Canadian population
Objective: To evaluate the awareness of and attitudes toward various aspects of sun-exposure risks and protection methods among Canadians. Methods: An online survey conducted from September 28 to O…
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pTERT mutational status is associated with survival in stage IV melanoma patients receiving first-line immune therapy
Background: TERT promoter mutations are the most prevalent mutations in melanoma. In this study, we investigated clinical characteristics and survival after first line therapies in a cohort of melanom…
Patients’ perceptions and attitudes regarding the use of AI in skin cancer screening and diagnosis
Artificial intelligence (AI) could enable early diagnosis of skin cancer; however, how AI should be implemented in clinical practice is debated. This narrative literature review (16 studies; 2012–2024…
Effect of prior and first-line immunotherapy on baseline immune biomarkers and modulation of the tumor microenvironment in response to nivolumab and relatlimab combination therapy in patients with melanoma from RELATIVITY-020
Background: Some patients with melanoma experience disease progression during immunotherapy (IO) and may benefit from novel combinations of immune checkpoint inhibitors (ICIs). We report results from…
AI-generated cancer prevention influencers can target risk groups on social media at low cost
Background: This study explores the potential of Artificial Intelligence (AI)-generated social media influencers to disseminate cancer prevention messages. Utilizing a Generative AI (GenAI) applicatio…
Review of participant recruitment and retention in randomised controlled trials of melanoma surveillance
Background: This scoping review aims to collate and describe data on recruitment, retention, and strategies used to improve these, in randomised controlled trials of melanoma surveillance. Methods: W…
Health-related Quality of Life and hospital costs of Finnish melanoma patients participating in the second Multicenter Selective Lymphadenectomy Trial (MSLT-II)
Background and purpose: After reports that complete lymph node dissection (CLND) did not improve melanoma-specific survival of sentinel lymph node (SLN)-positive patients, the use of CLND has diminis…
Genomic mediators of acquired resistance to immunotherapy in metastatic melanoma
Although some patients with metastatic melanoma experience durable responses to immune checkpoint inhibitors (ICIs), most exhibit intrinsic or acquired resistance to these therapies. Here, we compare …