Category: Research
Enhancing skin cancer prevention and awareness in the Italian population: Insights from the “Save Your Skin” screening campaign
Introduction: Skin cancer prevention campaigns aim to reduce modifiable risk factors, yet high-risk groups often maintain inadequate protection practices. Objectives: This study analyzed data from …
Majority of patients with melanoma experience substantial atherosclerotic plaque growth during ICI therapy
Background: Immune checkpoint inhibitors (ICIs) are effective anticancer agents but significantly increase cardiovascular risk. This could be due to its potential to induce or worsen atherosclerosis.…
Genetic test for skin cancer shows potential for accelerating early personalized chemoprevention in ultra-high risk transplant patients
Background: Transplant patients are at extreme risk of multiple invasive skin cancers. Chemopreventive medication can reduce this risk by ∼50%, but clinicians are unable to identify high-risk patient…
Neoadjuvant treatment with cobimetinib and atezolizumab±vemurafenib associated with low rate of distant metastasis in patients with high-risk stage III melanoma
Background: Neoadjuvant treatment has become standard for patients with high-risk operable stage III melanoma, but the optimal regimen is unknown. Targeted therapy approaches yield high pathological …
Clinical validation of droplet digital PCR assays in detecting BRAFV600-mutant circulating tumour DNA as a prognostic biomarker in patients with resected stage III melanoma receiving adjuvant therapy
Background: Cell-free, circulating tumour DNA (ctDNA) is an established measure of minimal residual disease; however, it is not utilised in melanoma management. We investigated whether ctDNA measurem…
Longitudinal analysis reveals dynamic changes in histopathologic features in responders to neoadjuvant treatment in a stage III BRAF-mutant melanoma cohort
Despite advances in systemic therapies, cutaneous melanoma remains a highly deadly disease. Patients with high-risk stage III melanoma have a significant likelihood of recurrence following surgery. Al…
Peripheral positioning of lysosomes supports melanoma aggressiveness
Emerging evidence suggests that the function and position of organelles are pivotal for tumor cell dissemination. Among them, lysosomes stand out as they integrate metabolic sensing with gene regulati…
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Integrated analysis of molecular and clinical features associated with overall survival in melanoma patients with brain metastasis
Melanoma brain metastases (MBMs) are diagnosed in up to 60% of metastatic melanoma patients. Previous studies have identified clinical factors that correlate with overall survival (OS) after MBM diagn…
Metabolic reprogramming of dendritic cells as a new approach for melanoma immunotherapy
Melanoma, being one of the most dangerous forms of skin cancer, is characterized by its aggressive and metastatic nature, with the potential to develop resistance to various treatments. This resistanc…
Relevance and need of gender-sensitive psychosocial-care in long-term survivors of malignant melanoma
Background: Optimism and pessimism are stable, overarching dispositions that influence mental health, especially in stressful life situations, such as cancer survival. They have been associated with m…