May 12, 2025, 12:00 AM
Immune checkpoint inhibition in metastatic or non-resectable melanoma after failure of adjuvant anti-PD-1 treatment
Background: Adjuvant immune checkpoint inhibition (ICI) with anti-PD-1 antibodies in high-risk resected melanoma has been shown to improve recurrence-free survival. It is unclear whether prior adjuvan…
Trial offering new treatment combination for melanoma brain metastases
The BETTER trial, recently activated in Australia, is testing a new treatment combination for melanoma that has spread to the brain, with the goal of improving outcomes for patients facing a poor prog…
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Melanoma in England: incidence is up, mortality is down
In recent decades, the epidemiology of cutaneous melanoma has undergone profound changes in many populations around the world, with steep rises in incidence set against recent declines in mortality. I…
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Prognostic and predictive value of IDO expression in metastatic melanoma treated with Ipilimumab
Background: The tumor microenvironment is crucial for prognosis and response to immunotherapy in several tumor entities. Methods: In a multicenter retrospective study, a total of 86 tumor samples f…