Category: Research
High variability in diagnoses highlights diagnostic challenges of early-stage melanomas and a need to reconsider how ground truth is established in routine care and AI research
Accurate melanoma diagnosis is crucial for patient outcomes and reliability of AI diagnostic tools. We assess interrater variability among eight expert pathologists reviewing histopathological images …
Female survival advantage in melanoma largely a result of indirect effect of sex mediated by clinicopathologic features
Sex differences in melanoma are prominent, with female having a significant survival advantage. However, it is unclear why we see this survival advantage. Here, we investigate the relationship between…
T helper 2 cell–directed immunotherapy eliminates precancerous skin lesions
The continuous rise in skin cancer incidence highlights an imperative for improved skin cancer prevention. Topical calcipotriol-plus–5-fluorouracil (calcipotriol-plus–5-FU) immunotherapy effectively e…
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Association between low vitamin D status and both increased melanoma risk and worsened prognosis
Background/Aim: Solar ultraviolet radiation represents the most important environmental risk factor for skin cancer. However, vitamin D synthesis from sun exposure has been reported to exert anti-car…
TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis
The TGFβ signaling pathway is known for its pleiotropic functions in a plethora of biological processes. In melanoma, TGFβ signaling promotes invasiveness and metastasis formation. However, its involv…
Short-term effectiveness of a stepped-care model to address fear of cancer recurrence in patients with early-stage melanoma
Objective: To investigate the effectiveness of the Melanoma Care Programme when implemented into routine clinical practice coupled with fear of cancer recurrence (FCR) screening and a stepped-care mo…
Consistently younger age at melanoma diagnosis of women vs. men suggests a need for tailored approaches to melanoma control
Background: Understanding the factors that influence age at melanoma diagnosis by sex and anatomical site is crucial for developing effective prevention and early detection strategies. While previous …
Three-year overall survival with nivolumab plus relatlimab in advanced melanoma from RELATIVITY-047
Nivolumab plus relatlimab demonstrated a statistically significant improvement in progression-free survival (PFS), along with a clinically meaningful, but not statistically significant improvement in …
Effectiveness of cross-sector collaboration in strategy implementation and impact: Evaluation of the NSW Skin Cancer Prevention Strategy 2016-2022
Issues addressed: Australia continues to have one of the highest rates of skin cancer in the world. In NSW, melanoma is the third most common cancer diagnosed. At least 95% of skin cancers are caused…
Prognostic significance of miRNA subtypes in melanoma
Background and Objectives: Melanoma remains a leading cause of skin cancer mortality despite advancements in targeted therapies and immunotherapies. MicroRNAs (miRNAs) have emerged as potential bioma…
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