Category: Research
Patients with resected stage IIB/C melanoma treated with adjuvant nivolumab demonstrated stable health-related quality of life, minimal bother from side effects
Background: In the phase 3 CheckMate 76 K trial, adjuvant nivolumab significantly improved recurrence-free survival and distant metastasis-free survival versus placebo in patients with resected stage …
Significant reduction in surgical interventions for melanoma in upcoming years
Melanoma surgery has evolved from elective lymph node dissection (ELND) to sentinel lymph node biopsy (SLNB) and wide local excision (WLE) margins have come down from 5 cm to nowadays 1 – 2 cm. Recent…
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Real-life cohort of patients with resected high-risk melanoma treated by adjuvant anti-PD1 therapy: nearly half of patients underwent recurrences, RFS at 24 months was 64%
Background: Programmed cell death protein-1 (PD1) antibodies are currently the standard treatment for resected high-risk melanoma, yet recurrence rate remains high. Objectives: This real-life observa…
Benefits of photoprotection should be taught early to children, caregivers, and parents of all skin tones
Background: Early childhood sun exposure contributes to lifetime risk of skin cancer. Many individuals from diverse ethnic backgrounds believe their skin tone confers immunity to sun damage; however,…
Predictive factors for development of in-transit metastasis in patients with melanoma
Background: In patients with melanoma, in-transit metastasis (ITM) can develop. This study aimed to identify the risk for a first recurrence of ITM and associated predictive clinical factors in a larg…
ZEB1-mediated regulation of PD-L1 tumor expression could contribute to immune escape in melanoma
Tumor cells can evade antitumor immune response by expressing the PD-L1 ligand, leading to the inhibition of PD-1-expressing T lymphocytes. The mechanisms that regulate PD-L1 expression in cancer cell…
Study on sun exposure and associated risks in the Canadian population
Objective: To evaluate the awareness of and attitudes toward various aspects of sun-exposure risks and protection methods among Canadians. Methods: An online survey conducted from September 28 to O…
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pTERT mutational status is associated with survival in stage IV melanoma patients receiving first-line immune therapy
Background: TERT promoter mutations are the most prevalent mutations in melanoma. In this study, we investigated clinical characteristics and survival after first line therapies in a cohort of melanom…
Patients’ perceptions and attitudes regarding the use of AI in skin cancer screening and diagnosis
Artificial intelligence (AI) could enable early diagnosis of skin cancer; however, how AI should be implemented in clinical practice is debated. This narrative literature review (16 studies; 2012–2024…
Effect of prior and first-line immunotherapy on baseline immune biomarkers and modulation of the tumor microenvironment in response to nivolumab and relatlimab combination therapy in patients with melanoma from RELATIVITY-020
Background: Some patients with melanoma experience disease progression during immunotherapy (IO) and may benefit from novel combinations of immune checkpoint inhibitors (ICIs). We report results from…