Category: Research
Androgen receptor aids diagnostic guidance in melanoma
Malignant melanoma represents the fifth most common cancer in the world and its incidence is rising. Novel therapies targeting receptor tyrosine kinases, kinases and immune checkpoints have been emplo…
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Importance of patient education on cumulative lifetime UV exposure through car windows
UV-A exposure is a major risk factor for melanoma, nonmelanoma skin cancer, photoaging, and exacerbation of photodermatoses. Since people spend considerable time in cars daily, inadequate UV-A attenua…
Increased risk of developing skin cancer in organ transplant recipients receiving immunosuppressive therapy with azathioprine
Background: Immunosuppression might increase the risk of skin cancer in organ transplant recipients (OTRs), with azathioprine (AZA), exerting a fundamental role in the carcinogenesis of those tumors. …
Comparison of real-world data on adjuvant treatment in patients with stage III BRAF V600 mutated melanoma
Background: Over the past decade, PD-1-based immune checkpoint inhibitors (ICI) and targeted therapies (TT) with BRAF and MEK inhibitors transformed melanoma treatment. Both are widely used in the adj…
High variability in diagnoses highlights diagnostic challenges of early-stage melanomas and a need to reconsider how ground truth is established in routine care and AI research
Accurate melanoma diagnosis is crucial for patient outcomes and reliability of AI diagnostic tools. We assess interrater variability among eight expert pathologists reviewing histopathological images …
Female survival advantage in melanoma largely a result of indirect effect of sex mediated by clinicopathologic features
Sex differences in melanoma are prominent, with female having a significant survival advantage. However, it is unclear why we see this survival advantage. Here, we investigate the relationship between…
Ferroptosis: a targetable vulnerability for melanoma treatment
Melanoma is a devastating form of skin cancer characterized by a high mutational burden, limited treatment success, and dismal prognosis. Although immunotherapy and targeted therapies have significant…
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T helper 2 cell–directed immunotherapy eliminates precancerous skin lesions
The continuous rise in skin cancer incidence highlights an imperative for improved skin cancer prevention. Topical calcipotriol-plus–5-fluorouracil (calcipotriol-plus–5-FU) immunotherapy effectively e…
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Association between low vitamin D status and both increased melanoma risk and worsened prognosis
Background/Aim: Solar ultraviolet radiation represents the most important environmental risk factor for skin cancer. However, vitamin D synthesis from sun exposure has been reported to exert anti-car…
TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis
The TGFβ signaling pathway is known for its pleiotropic functions in a plethora of biological processes. In melanoma, TGFβ signaling promotes invasiveness and metastasis formation. However, its involv…