Category: Research
Circulating tumor DNA assessment shows promising results in predicting and reflecting disease status during adjuvant therapy
Background: The introduction of adjuvant therapies for patients with resected cutaneous melanoma (CM) has increased the need for sensitive biomarkers for risk stratification and disease monitoring. Th…
Melacare nurse-led intervention feasible and acceptable for use with patients treated for early-stage melanoma
Background and purpose: We developed the Melacare nurse-led intervention, which combines education in skin self-examination as a resource-conscious approach to detecting recurrence and management of …
PDE4D drives rewiring of MAPK pathway in BRAF-mutated melanoma resistant to MAPK inhibitors
Background: Phosphodiesterase type 4D (PDE4D) breaks down cyclic AMP (cAMP) reducing the signaling of this intracellular second messenger which plays a major role in melanocyte pathophysiology. In adv…
Relapse-free survival with adjuvant dabrafenib/trametinib therapy after relapse on a prior adjuvant CPI in BRAF V600-mutated stage III/IV melanoma
Background: In BRAF-mutated high-risk melanoma, targeted therapy (BRAF/MEK inhibitors) and checkpoint inhibitor (CPI) immunotherapy have durable benefits as first-line (1L) adjuvant therapy. Based on …
Impact of personalized response-directed surgery and adjuvant therapy on survival after neoadjuvant immunotherapy in stage III melanoma: Comparison of 3-year data from PRADO and OpACIN-neo
Background: Pathologic response following neoadjuvant immune checkpoint blockade (ICB) in stage III melanoma serves as a surrogate marker for long-term outcomes. This may support more personalized, re…
E-cigarettes may contribute to the development of oral squamous cell carcinoma
Electronic cigarettes are widely used by young adults, yet their impact on oral health, specifically in the context of oral squamous cell carcinoma (OSCC), is poorly understood. This study aimed to ev…
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Molecular insights into the role of electronic cigarettes in oral carcinogenesis
Electronic cigarette (EC) usage or vaping has seen a significant rise in recent years across various parts of the world. They have been publicized as a safe alternative to smoking; however, this is no…