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Nov 25, 2024, 12:00 AM
PDE4D drives rewiring of MAPK pathway in BRAF-mutated melanoma resistant to MAPK inhibitors
Background: Phosphodiesterase type 4D (PDE4D) breaks down cyclic AMP (cAMP) reducing the signaling of this intracellular second messenger which plays a major role in melanocyte pathophysiology. In adv…