Category: Research
Is wide local excision after primary excision of melanoma in situ unnecessary?
Dessinioti and coauthors1 present a retrospective study undertaken in Greece reporting the clinical outcomes for 401 people diagnosed and treated for melanoma in situ from 1991 to 2023 at a major mela…
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Sentinel lymph node biopsy review: historical trajectory, current guidelines and controversies, future directions
Sentinel lymph node biopsy (SLNB) has transformed the management of cutaneous melanoma, emerging as a cornerstone in evaluating regional lymphatic spread while minimizing surgical morbidity. From its …
Higher serum 25(OH)D levels associated with increased skin cancer risk, likely reflecting cumulative UV exposure
Background and objectives: Skin cancer, the most common global malignancy, is linked to ultraviolet (UV)-driven serum 25-hydroxyvitamin D (25(OH)D)synthesis, with its controversial role possibly refle…
The epiMelanoma test enables plasma-based detection of melanoma and prediction of immunotherapy response
Background: Melanoma is one of the most serious skin cancers worldwide, often progressing without obvious symptoms. Early detection is crucial to enable timely intervention, reducing morbidity and mor…
Systematic review of molecular basis of BRAF inhibitor resistance in melanoma
Background: Melanoma, the deadliest human skin cancer, frequently harbors activating BRAF mutations, with V600E being the most prevalent. These alterations drive constitutive activation of the MAPK p…
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COVID‐19 pandemic contributed to delayed melanoma diagnoses and shift towards more advanced disease at presentation
Background: The COVID‐19 pandemic has significantly disrupted global healthcare systems. Melanoma, a highly aggressive skin cancer whose prognosis is closely tied to early detection, has been particu…
Comparison between cutaneous, mucosal, acral, nail, and ocular melanoma malignancy
A melanoma is a malignant neoplasm that originates from melanocytes. Melanocytes are found in various body sites—they are most commonly found in the skin (including acral sites and nail units), ocular…
A diagnosis of dysplastic naevus has no clinical relevance and unnecessarily confounds therapeutic decision-making
The term ‘dysplastic naevus’ first introduced in 1980, has since engendered considerable debate regarding its ontological legitimacy, the appropriateness of its nomenclature, and its potential prognos…
Low triglyceride levels are associated with increased risk of immune-related adverse events in patients receiving immune checkpoint inhibitors
Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy by enhancing anti-tumor immune responses, yet their use can lead to immune-related adverse events (irAE), including neurological c…
Solid phase micro extraction of volatile organic compounds (VOC) shows promise for future study of V
Introduction: Skin cancer sites are known to release volatile organic compounds (VOCs) and these compounds can be collected and analysed to aid in the chemical profiling of skin cancers. Patients an…