Category: Research
Melanoma brain metastasis: new molecular insights and therapeutic directions
Melanoma, a highly aggressive and metastatic cancer, poses significant challenges due to its propensity to spread to distant organs, with brain metastasis representing a particularly devastating compl…
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Ancestry and somatic profile indicate acral melanoma origin and prognosis
Acral melanoma, which is not ultraviolet-associated, is the type of melanoma reported most commonly in several non-European-descent populations1,2,3, including in Mexican people4. Latin American sampl…
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Real-world evidence on adverse event management and time on therapy with adjuvant dabrafenib plus trametinib in patients with BRAF V600-mutant melanoma
Background/Objectives: Malignant melanoma is a highly aggressive cancer associated with significant mortality, underscoring the need for continued research efforts. COMBI-EU (NCT03944356) is a prospe…
Findings of randomized clinical trial support use of adjuvant pembrolizumab in high-risk stage II melanoma
Importance: Patients with melanoma are at risk of developing subsequent cutaneous malignant neoplasms, and the effect of prior immunotherapy is unknown. Objective: To analyze new skin cancers in …
Transcription factor HOXD13 drives melanoma growth and immune evasion
Ultraviolet (UV)-induced DNA mutations generate genetic drivers of cutaneous melanoma and numerous neoantigens that can trigger anti-tumor immunity. Melanoma cells must therefore rapidly evade immune …
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Study establishes a pan-skin cancer immune remodelling framework, providing a foundation for biomark
Background: Skin cancers, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), cutaneous melanoma (CM) and acral melanoma (AM), exhibit profound heterogeneity in clinical behaviour and…
Formative research to inform an Australian innovative mass-reach national skin cancer prevention campaign
Issue Addressed: With high skin cancer rates, Australia faces challenges in encouraging young people to think differently about their sun protection behaviours, particularly in an evolving media envir…
Knowledge, attitudes and behaviour towards sun protection and ultraviolet radiation exposure: survey findings
New research reveals concerning sunburn rates and strong public support for skin cancer prevention in New Zealand.
Melanoma Care Program to help early-stage melanoma patients manage fear of recurrence maintained effectiveness at 6- and 12-month follow-up
Purpose: To investigate the effectiveness of the Melanoma Care Program, an evidence-based, psychological intervention delivered through a stepped-care model, to address fear of cancer recurrence (FCR)…
Protocol for a microsimulation model of risk-tailored melanoma screening
In populations of European descent, melanoma is a high burden cancer in terms of incidence and healthcare costs, with early detection linked to better prognosis. There is no organised population scree…
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