Category: Research
Polymer nanofiber-based electrodes for tyrosinase detection in melanoma diagnosis: scalable, cost-effective melanoma screening
The rising global incidence of melanoma and its high mortality rates due to late diagnosis demand rapid, sensitive, and non-invasive diagnostic tools. Here, we introduce a disposable electrochemical b…
Dermatoscopy may offer valuable prognostic insights into melanoma’s biological behavior before excision and help guide therapeutic decisions
Current melanoma prognostic tools have limited clinical use at the bedside, highlighting the need for more effective biomarkers. Dermatoscopy correlates with established prognostic markers obtained th…
Review: cutaneous melanoma in the context of aging
Ageing is sustained by a complex network of cellular and molecular mechanisms. The main mechanisms are cellular senescence, telomere attrition, gene expression changes, metabolic dysregulations, oxida…
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Semaphorin 5 A is a novel player of melanoma aggressiveness and progression
Introduction: Metastatic potential and rising incidence make cutaneous melanoma a major health concern worldwide. While current therapies have proven effective, they are limited by side effects arisin…
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Circulating IFNγ-associated protein signatures predict response to neoadjuvant immunotherapy in patients with stage III melanoma
Background: Immune checkpoint inhibitors (ICIs), such as anti-programmed cell death protein 1 (PD-1) and anti-cytotoxic T-lymphocyte associated protein 4 (CTLA-4), have transformed the management of s…
Tattoos may be a risk factor for cutaneous melanoma
The incidence of cutaneous melanoma (CM) has risen sharply over the past 30 years, coinciding with the rapidly growing tattoo trend. In Sweden, 20% of the population is tattooed. Repeated reports of t…
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RAS(ON) multi-selective inhibition offering the first targeted approach for patients with NRAS-mutant melanoma
Targeted therapies for NRAS-mutant melanoma remain an unmet clinical need. Here, we demonstrate that RMC-7977, a preclinical RAS(ON) multi-selective inhibitor representative of the investigational age…
Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors
Patients who initially respond to immune checkpoint inhibitors (ICIs) often relapse. Here, we studied how disease-progressive (DP) clinical melanomas evolve genomically to acquire ICI resistance. Comp…
Review of keratinocyte carcinoma
Importance: Keratinocyte carcinomas are skin cancers that arise from keratinocytes and are composed of basal cell carcinomas (BCCs) and cutaneous squamous cell carcinomas (cSCCs). Keratinocyte carcino…
Stage II melanoma: Is there a “simple trick” to significantly improve event-free survival?
On occasion, a therapeutic development makes a meaningful difference in patient outcomes without involvement of a new, expensive drug. An outstanding example of this in melanoma is the adoption of neo…