Category: Research
Melanoma patients receiving combination anti-PD-1/CTLA-4 immunotherapy have greater longterm risk of neurologic immune-related adverse events than patients receiving anti-PD-1 monotherapy
Background: Over the past decade, novel immune checkpoint inhibitors have revolutionized melanoma treatment. These new therapies are associated with complex immune-related adverse events. This study e…
Tumor infiltrating lymphocytes in primary melanoma associated with better prognosis
Background: The relationship between tumor infiltrating lymphocytes (TIL) and survival in melanoma is poorly understood. We present a large multicenter study assessing the association between TIL and …
Benefit of adjuvant pembrolizumab on recurrence-free survival and distant metastasis-free survival in patients with resected high-risk stage II melanoma, irrespective of primary tumor location
Background: Previous results from the KEYNOTE-716 trial demonstrated significantly improved recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) with adjuvant pembrolizumab versu…
Melanomas associated with pre-existing nevi appear to be an independent favorable prognostic factor for recurrence and survival
Background: Although most melanomas develop de novo, about 30% are nevus-associated melanomas, where the prognostic value is unclear. Our study aimed to determine whether nevus-associated melanoma is …
Sun protection apps emphasizing knowledge, ease of use, tailored advice, and proactive features likely to encourage sustained engagement
Background: Sunburn and intermittent sun exposure elevate melanoma skin cancer risk. Sun protection behaviours, including limiting sun exposure, seeking shade, wearing protective gear, and using suns…
Biofeedback information can increase risk perceptions related to skin cancer and initiate intended behaviour change
Background: The incidence of skin cancer among Danes is one of the highest in the world. Most skin cancers are, however, avoidable with sun protection and reduction of exposure. One way to increase aw…
Androgen receptor aids diagnostic guidance in melanoma
Malignant melanoma represents the fifth most common cancer in the world and its incidence is rising. Novel therapies targeting receptor tyrosine kinases, kinases and immune checkpoints have been emplo…
Read more about 'Androgen receptor aids diagnostic guidance in melanoma'...
Importance of patient education on cumulative lifetime UV exposure through car windows
UV-A exposure is a major risk factor for melanoma, nonmelanoma skin cancer, photoaging, and exacerbation of photodermatoses. Since people spend considerable time in cars daily, inadequate UV-A attenua…
Increased risk of developing skin cancer in organ transplant recipients receiving immunosuppressive therapy with azathioprine
Background: Immunosuppression might increase the risk of skin cancer in organ transplant recipients (OTRs), with azathioprine (AZA), exerting a fundamental role in the carcinogenesis of those tumors. …
Comparison of real-world data on adjuvant treatment in patients with stage III BRAF V600 mutated melanoma
Background: Over the past decade, PD-1-based immune checkpoint inhibitors (ICI) and targeted therapies (TT) with BRAF and MEK inhibitors transformed melanoma treatment. Both are widely used in the adj…