Category: Research
Clinical validation of droplet digital PCR assays in detecting BRAFV600-mutant circulating tumour DNA as a prognostic biomarker in patients with resected stage III melanoma receiving adjuvant therapy
Background: Cell-free, circulating tumour DNA (ctDNA) is an established measure of minimal residual disease; however, it is not utilised in melanoma management. We investigated whether ctDNA measurem…
Longitudinal analysis reveals dynamic changes in histopathologic features in responders to neoadjuvant treatment in a stage III BRAF-mutant melanoma cohort
Despite advances in systemic therapies, cutaneous melanoma remains a highly deadly disease. Patients with high-risk stage III melanoma have a significant likelihood of recurrence following surgery. Al…
Peripheral positioning of lysosomes supports melanoma aggressiveness
Emerging evidence suggests that the function and position of organelles are pivotal for tumor cell dissemination. Among them, lysosomes stand out as they integrate metabolic sensing with gene regulati…
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Integrated analysis of molecular and clinical features associated with overall survival in melanoma patients with brain metastasis
Melanoma brain metastases (MBMs) are diagnosed in up to 60% of metastatic melanoma patients. Previous studies have identified clinical factors that correlate with overall survival (OS) after MBM diagn…
Metabolic reprogramming of dendritic cells as a new approach for melanoma immunotherapy
Melanoma, being one of the most dangerous forms of skin cancer, is characterized by its aggressive and metastatic nature, with the potential to develop resistance to various treatments. This resistanc…
Relevance and need of gender-sensitive psychosocial-care in long-term survivors of malignant melanoma
Background: Optimism and pessimism are stable, overarching dispositions that influence mental health, especially in stressful life situations, such as cancer survival. They have been associated with m…
Predictive factors for sentinel lymph node positivity in melanoma patients: the role of liquid biopsy, microRNA and gene expression profile panels
The identification of predictive factors for sentinel lymph node (SLN) positivity in melanoma patients is crucial for accurate staging, prognosis, and personalized therapeutic decisions. This review s…
Stereotactic radiosurgery (SRS) is an effective treatment for melanoma brain metastases, with low risk of haemorrhage after SRS
Purpose: Melanoma brain metastases (MBM) pose significant challenges in management due to their propensity for intralesional haemorrhage. This retrospective analysis aims to evaluate the oncological o…
Molecular analysis of cutaneous sarcomatoid neoplasms frequently identifies melanoma driver variants
Primary cutaneous neoplasms that lack definitive histologic and immunophenotypic evidence of differentiation are a heterogeneous group of tumors with diverse prognoses and management options. These in…
Wide local excision does not significantly improve recurrence-free survival in patients with completely excised cutaneous superficial spreading and nodular melanoma on trunk or extremities
Objectives: This study examines whether wide local excision (WLE) after complete diagnostic excision improves recurrence-free survival (RFS) in clinical stage I/II primary cutaneous melanoma. Backgro…