Knowledge of cancer development and progression gained over the last few decades has enabled mapping of genetic and epigenetic changes unique to different phases of tumor evolution. Here we focus on epigenetic changes that drive melanoma development and progression. We highlight the importance of epigenetic mechanisms which encompass crosstalk with melanoma microenvironment that affect metastasis and therapy resistance. This review summarizes recent advances and describes potential strategies to leverage this knowledge to devise new therapies.

Source:

Hyunjeong Joo, Ximena Diaz Olea, Aojia Zhuang, Bin Zheng, Hyungsoo Kim, Ze’ev A. Ronai, Epigenetic mechanisms in melanoma development and progression, Trends in Cancer, Volume 11, Issue 8, 2025, Pages 736-752,
ISSN 2405-8033, https://doi.org/10.1016/j.trecan.2025.04.007.

https://www.sciencedirect.com/science/article/pii/S2405803325000998