Dec 15, 2025, 12:00 AM
9-year final data support sustained finding of longer recurrence-free survival with nivolumab than with ipilimumab for resected stage III or IV melanoma
Background: In the CheckMate 238 trial, patients with resected stage IIIB–C or stage IV melanoma who were treated with nivolumab had longer recurrence-free survival than those who received ipilimumab.…
Adjuvant nivolumab plus relatlimab does not improve recurrence-free survival compared with nivolumab alone after complete resection of stage III/IV melanoma
Based on RELATIVITY-047, nivolumab plus relatlimab is approved for advanced melanoma. Here, to address a current unmet need for more efficacious adjuvant regimens for completely resected melanoma, the…
Association between painful, blistering, and/or severe sunburns and cSCC
Importance: While UV radiation is a known carcinogen associated with cutaneous squamous cell carcinoma (cSCC), sunburn’s specific role remains less clear. Objective: To quantitatively assess the asso…
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Risk factors for incident nevus-associated vs de novo invasive melanoma
Importance: No prospective epidemiologic studies have investigated genetic vs environmental factors on the risks of nevus-associated melanoma (NAM) and de novo melanoma. Objective: To determine wheth…
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Nicotinamide for skin cancer chemoprevention
Importance: Nicotinamide supplementation has been studied as a chemopreventive medication for reducing skin cancer risk, but large-scale data are limited. Objective: To determine the clinical efficac…
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